Postdoctoral Fellow - Genetics - chaperone protein HSP90

Tumor cells must endure diverse intrinsic and extrinsic stressors that perturb proteome homeostasis. By serving as a protein-folding buffer within the cell, the chaperone protein HSP90 supports protein homeostasis and enables tumor cells to survive and rapidly evolve resistance to therapies. For this, HSP90 must bind to diverse proteins and stabilize them within the cytoplasm. However, the specific mechanisms through which HSP90 fosters cancer evolution remain obscure. We will examine these HSP90-dependent mechanisms using multiomic systems approaches and functional genomics methodologies, and subsequently, we will validate the mechanisms we identify in mice. This strategy will identify novel cancer therapies that limit the ability of tumors to evolve resistance.

LEARNING OBJECTIVES
The postdoctoral fellow will engage with the PI to understand how the HSP90 chaperone is regulated in cancer and how it supports DNA repair in tumor cells. This will require a deep interest in cell biology and signaling pathway biology. The PI will mentor the postdoctoral fellow in laboratory approaches that may be unfamiliar and in critical thought, experimental design, and bringing new perspectives to the laboratory. Training that may be needed that is outside of the expertise of the PI will involve attending courses or engaging in collaborative ventures. A major part of the learning objectives will involve optimizing scientific communication, both written and oral, which includes developing robust networks of colleagues to enhance one's work in the laboratory and to promote the trainee's research program after leaving the laboratory.

ELIGIBILITY REQUIREMENTS
We seek highly motivated postdocs interested in functional proteomics, quantitative genetics, biochemistry, cell biology, or cancer biology. We welcome applicants from diverse backgrounds who wish to apply their expertise to biological systems and contribute to the advancement of precision medicine. The minimum requirement is to have recently been awarded (within two years) a Ph.D.

ADDITIONAL APPLICATION INFORMATION
For more information: Gerogios Karras, Ph.D. (insert hyperlink below)
https://faculty.mdanderson.org/profiles/georgios_karras.html_gl=1*ggepb0*_ga*MTU3NDkzMTk2My4xNjc0MjQ0MjQ4*_ga_E3Z52F3KSB*MTY3NzUxMTgxNy4xMC4xLjE2Nzc1MTE4MTkuMC4wLjA.

Karras Lab (insert hyperlink below)
https://www.mdanderson.org/research/departments-labs-institutes/labs/karras-laboratory.html