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Principal Scientist - siRNA Analytics

San Diego, California, United States
Closing date
Mar 20, 2023

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Health Sciences, Drug Development
Position Type
Full Time
Job Type
Staff Scientist
Organization Type

Job Details

Job Description

4 FDA approved drugs; 15+ clinical candidates; 400+ patents; 21 years of NIBR - San Diego history!
The Global Discovery Chemistry Analytical team is seeking a highly motivated Principal Scientist to help drive innovation in targeted siRNA delivery. As one of the local scientific leaders in siRNA, you will be working closely with a global team of experts to advance our therapeutics and to drive our understanding of selective delivery of siRNA.

Your responsibilities include, but are not limited to,
• Characterization of oligos and siRNA using appropriate analytical techniques
• Evaluate oligonucleotide PK and metabolism in cells, tissues, and biofluids, using standard oligonucleotide analytical methods (Stem-loop RT-qPCR, PNA fluorescence hybridization, or LC-MS)
• Design, develop, and troubleshoot SOPs for bioanalytical assays
• Identify and drive the identification of solutions to innovate the field of siRNA therapeutics
• Learning agility towards new concepts and ability to incorporate and exploit ideas across different teams
• Summarize and present results to team members
• Apply automation or collaborate with automation experts to improve efficiency

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you’ll bring to the role:
• PhD in Analytical, Organic Chemistry, or Biochemistry with 4 years of work experience in a pharmaceutical or biopharmaceutical organization
• Good understanding of RNA biology and RNA therapeutics
• Broad experience in analytical techniques for oligonucleotides (ASOs and siRNAs), various oligonucleotides conjugates, including, but not limited to, HPLC-UV/Fluorescence/MS and gel/capillary electrophoresis
• Skilled with bioanalytical techniques, including stem-loop RT-PCR and hybridization assays, for siRNA quantification in biofluids and tissues
• Experience measuring gene expression by qPCR
• Excellent oral and written communication, interpersonal skills, and a team-player mindset
• Demonstrated ability in taking initiative and driving projects
• Experience with automated liquid handling/assay automation desirable
• Experience with protein quantification and biomarker analysis by ELISA, Gel Electrophoresis, Western Blotting/WES/JESS would be a plus

Why Novartis?

766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.

We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!

Imagine what you could do here at Novartis!

Commitment to Diversity & Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

Accessibility and Reasonable Accommodations: Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please send an e-mail to [email protected] or call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

The pay range for this position at commencement of employment is expected to be between $112, 000 to $169,000 /year; however, while salary ranges are effective from 1/1/22 through 12/31/22, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here:


At Novartis, we are reimagining medicine.

Our purpose is to reimagine medicine to improve and extend people's lives. We use innovative science and technology to address some of society's most challenging healthcare issues. We discover and develop breakthrough treatments and find new ways to deliver them to as many people as possible.

Novartis has one of the industry’s most competitive pipelines. Many of these projects, which include new molecular entities as well as additional indications and different formulations for marketed products, are for medicines that could significantly advance treatment standards for patients worldwide.

We have entered an exciting era in health and biomedical innovation. Powered by our incredible colleagues, supported by our flexible-hybrid working model, new AI powered learning, personal growth and career platform and a refreshed commitment to diversity, equity & inclusion, we are well-poised to help lead this transformative moment for our industry and for ourselves. Join Us!

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