Senior Scientist - Applied Synthesis Technologies (Flow Chemistry)

Groton, Connecticut
Closing date
Apr 8, 2023

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Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Working in the Applied Synthesis Technologies group within Medicine Design, you will apply cutting-edge chemical synthesis capabilities to accelerate the discovery of breakthrough medicines, aiding patients around the world.

What You Will Achieve

We are seeking a creative, highly motivated synthetic organic chemist to join our Pfizer Worldwide Research, Development and Medical laboratories based in Groton, CT. As part of the Applied Synthesis and Technology group within Medicine Design, the successful applicant will employ synthetic technologies, in particular continuous flow chemistry, to drive the advancement of programs across the small molecule portfolio. The successful applicant will work directly with medicinal chemistry project teams to deliver future pharmaceutical therapies. In addition to applying continuous flow chemistry, they will utilize a range of synthesis technologies which may include high-throughput experimentation, laboratory automation, parallel medicinal chemistry and/or biocatalysis.

How You Will Achieve It

Primarily, the successful applicant will identify opportunities for the application of continuous flow chemistry within Pfizer's early-stage pharmaceutical development programs and develop flow chemistry processes to advance the medicinal chemistry portfolio. In addition, their responsibilities will include:
  • Independent use of established and modern synthetic methodologies and technologies to drive projects.
  • Chemical synthesis of pharmaceutical intermediates to support medicinal chemistry programs
  • Working with internal and external partners to deliver continuous flow and other technology-based chemical syntheses
  • Utilization of state-of-the-art high-throughput experimentation (HTE) and analytical platforms to conduct research.
  • Development of new continuous flow chemistry-based technologies.
  • Contributing to and maintaining a comprehensive knowledge of organic chemistry and synthesis technology literature.
  • As a strong team player, working with partner lines to deliver on project goals via collaboration and clear communication.


Please submit your resume and a research summary with your application. A research summary is required to be considered for this position.


  • A PhD in a synthetic or a continuous flow chemistry related subject with 0-3 years of industrial experience or a BSc/MSc in a synthetic or a continuous flow-related subject with over 6 years of industrial experience is required.
  • Expert understanding of and significant laboratory experience conducting continuous flow chemistry is required.
  • An excellent track record of developing and executing chemical processes as well as contributions to the scientific literature are essential.
  • Comprehensive knowledge of established and modern chemical synthesis methodologies is required.
  • Strong analytical and chemical problem-solving skills are required.


  • Contributions to the continuous flow chemistry literature are desirable
  • Post-doctoral experience is desirable.
  • Knowledge of high-throughput experimentation, automation, synthesis technologies and/or modern analytical chemistry is an advantage.
  • Makes good decisions in a timely manner, sometimes under tight deadlines.
  • Capable of quickly adapting to changes in project direction.
  • Responds well to scientific challenges and applies significant rigor to own work.
  • Steadfastly pushes oneself to achieve results and deliver on goals.
  • Is seen as a team player and encourages collaboration.


Ability to design and execute chemical reactions in a laboratory environment.

Ability to perform mathematical calculations and complex data analysis.


Occasional and limited travel (0-5%) to support technology transfer or attend conferences/business meetings.

Work Location Assignment:On Premise


Relocation assistance may be available based on business needs and/or eligibility.


Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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