ORISE Fellowship to Study Neonatal Immunology/Immune Responses to mRNA Vaccines

Organization:  Cellular Immunology Group, Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research of the US FDA (CBER/FDA).

Background: Our laboratory is investigating the immunobiological mechanisms responsible for the suboptimal vaccine responses in newborns and infants. The goal of these studies is to improve the efficacies of pediatric vaccines using adjuvants targeting the pathways responsible for the blunted immune responses.

Project description: We are using neonatal mice from immunocompetent as well as various transgenic backgrounds to study the immune responses to diverse vaccine platforms including mRNA vaccines (SARS-CoV-2) and novel delivery systems. The analysis of immune response involves detailed investigation of the cellular and molecular mechanisms controlling the development of follicular helper T (Tfh) cells and germinal center B cells. The candidate will participate in experimental design, immunization and analyzing cellular and molecular responses to vaccines in addition to writing manuscripts and presenting her/his work in national and international meetings.

Qualifications:

• Doctoral degree in immunology, molecular biology, biochemistry or a related discipline, received within the last five years (Qualified candidates with master’s degree will also be considered)
• Excellent command of multi-color flow cytometry and standard immunology techniques is required
• Experience with RNA-seq, bioinformatics and single cells sequencing is preferred
• Previous mouse handling experience is a must
• Ability to work with others in a team environment
• Strong written and verbal communication skills
• Publication record in peer-reviewed journals

Location/Facilities:  The laboratory, located on the White Oak Campus in building 52/72 (Silver Spring, MD), is equipped with standard immunology, biochemistry and molecular biology equipments. CBER core facilities include Flow cytometry, Microscopy and Imaging, NextGen sequencing, Oligonucleotide synthesis, Peptide synthesis, Mass spectrometry analysis, among others.

Eligibility: This position will be appointed initially for 1 year with the potential for renewal.  Candidates must be within 5 years of receiving their highest degree and must have lived in the U.S. for a minimum of 3 of the last 5 years. Competitive stipend, correspond roughly to U.S. government GS scale, are commensurate with education and experience, and include an allowance for mandatory health insurance.

How to apply: Qualified candidates should send curriculum vitae and a list of 3 references with contact information to Mustafa Akkoyunlu, Mustafa.Akkoyunlu@fda.hhs.gov