- National Cancer Institute
- Bethesda, Maryland (US)
- Closing date
- May 17, 2023
- Life Sciences, Biochemistry, Biotechnology, Molecular Biology, Cancer Research
- Position Type
- Full Time
- Job Type
- PhD Fellowship
- Organization Type
Antibody Engineering, T cell engineering, Cancer Immunotherapy – Postdoctoral Fellowship
National Cancer Institute, Bethesda, MD
Dr. Mitchell Ho’s laboratory at the National Cancer Institute (NCI) Center for Cancer Research (CCR) has characterized cell surface proteins such as glypicans including GPC1, GPC2 and GPC3, B7-H3 (CD276), and mesothelin as immunotherapeutic targets in solid tumors such as liver cancer, pancreatic cancer and childhood cancers. We have used molecular and cellular biology, computational structure modeling, RNA sequencing (RNA-seq), and mouse tumor models to develop single-domain antibody (nanobody) technology, isolate antibodies targeting tumor-specific epitopes, and engineer CAR or TCR constructs for designing novel T cell-based immunotherapies. There are two postdoctoral positions available in the Ho lab, one for antibody discovery (phage display) and protein engineering in the antibody engineering core and the other for T cell engineering and preclinical testing using mouse tumor models in the antibody therapy section. Some of our research have the potential for direct clinical application.
Detailed information about our research program and publications can be accessed: https://ccr.cancer.gov/mitchell-ho
Candidates are expected to have completed, or be completing, a Ph.D. or M.D./Ph.D. with a strong publication record. Highly motivated candidates who are interested in innovative, high-impact basic and translational research are encouraged to apply. A background in biochemistry, molecular and cell biology, and/or biomedical engineering is required. Experience with mouse tumor models, RNA-seq, protein structure and/or computational skills is a plus.
Applications should be sent by e-mail to Dr. Mitchell Ho (firstname.lastname@example.org). Each application should consist of a cover letter describing your research experience and interests, curriculum vitae, bibliography, and contact information of three references.
This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs.
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