Postdoctoral Scholar in Structural Biology

Dr. Wei-Jen Tang is seeking a candidate to study structures and function of human amyloid peptide degrading proteases.  The Tang lab is broadly interested in understanding the molecular mechanisms underlying the activity of clinically relevant enzymes and their biomedical implications. Active projects include the study of human proteases involved in diabetes, Alzheimer’s disease, and neurological disorders, investigating the role of cytokines in inflammation, and exploring how bacterial toxins disrupt host cell processes (https://voices.uchicago.edu/wtang-lab/). The successful candidates will use integrative structural approaches such as cryoEM, X-ray crystallography, SAXS, HDX-MS, MD simulation, and protein evolution to investigate the structure and function of human proteases that degrade amyloidogenic peptides with the goal to address the molecular basis of how human proteases recognize amyloid peptides and develop therapeutic innovation to better maintain proteostasis.

We seek a highly motivated postdoctoral fellow with excellent English communication skills and the ability to work effectively within a research team to join an R01-supported research project. Successful candidates will be given latitude to develop a research project of personal interest within the umbrella of research interest in Dr. Tang’s lab. The Tang lab fosters a highly collaborative environment and offers the opportunity to interact with world-class researchers in the Chicago area and across the nation through longstanding and successful collaborations.

Required education and experience: Applicants must have a recent Ph.D. or equivalent degree in structural biology, biochemistry, or biophysics and a demonstrable record of research success as evidenced by publication(s) in peer-reviewed journals. Motivated candidates with a strong background in modern structural biology and biophysical techniques are highly desirable.

To apply: Interested applicants should submit their curriculum vitae, along with a cover letter stating their research interests and career goals, and the names and contact information of three references to Wei-Jen Tang (wtang@bsd.uchicago.edu). Salary will be based on experience and follow current NIH guidelines.