Postdoctoral Fellow - Herpesvirus Vaccine Development

About City of Hope

City of Hope's mission is to deliver the cures of tomorrow to the people who need them today. Founded in 1913, City of Hope has grown into one of the largest cancer research and treatment organizations in the U.S. and one of the leading research centers for diabetes and other life-threatening illnesses. City of Hope research has been the basis for numerous breakthrough cancer medicines , as well as human synthetic insulin and monoclonal antibodies. With an independent, National Cancer Institute-designated comprehensive cancer center at its core, City of Hope brings a uniquely integrated model to patients spanning cancer care, research and development, academics and training, and innovation initiatives. City of Hope's growing national system includes its Los Angeles campus, a network of clinical care locations across Southern California, a new cancer center in Orange County, California, andtreatment facilities in Atlanta, Chicago and Phoenix. City of Hope's affiliated group of organizations includes Translational Genomics Research Institute and AccessHope TM . For more information about City of Hope, follow us on Facebook , Twitter , YouTube , Instagram and LinkedIn .

City of Hope's commitment to Diversity, Equity and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all of our communities. Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds and experiences to our work -- and that our teams align with the people we serve in order to build trust and understanding. We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds and perspectives; this is reflected in our work and represented in our people.

Position Summary and Key Responsibilities

The laboratory of Javier Gordon Ogembo, Ph.D.at The Beckman Research Institute of City of Hope is looking for a talented Postdoctoral Fellow.

Our laboratory invites highly motivated candidates to apply for an interdisciplinary postdoctoral fellow position. Our laboratory focuses on oncogenic herpesviruses, in particular Epstein-Barr virus (EBV), Kaposi-sarcoma associated herpesvirus (KSHV), and the rhesus macaque EBV homologue rhesus lymphocryptovirus (rhLCV), and on developing prophylactic and therapeutic strategies against primary infection with these viruses and their associated cancers.

The postdoctoral fellow will work on projects with the overarching goal of designing and testing gamma herpesvirus vaccine candidates and immuno-therapeutics in various preclinical animal models.

The postdoctoral fellow will be leading projects that are in collaborations between the City of Hope Cancer Center and other institutions within and outside the USA. Importantly, City of Hope has good laboratory practice (GLP) and Current Good Manufacturing Practice (cGMP) FDA-approved biologic facilities ( https://www.cityofhope.org/research/biological-and-cellular-gmp-manufacturing-facility/cbg---center-for-biomedicine-and-genetics ) to produce the candidate vaccines and immunotherapeutics in house and test them in preclinical animal models and in Phase I clinical trials.

Basic education, experience and skills required for consideration:

• Candidates should have a Ph.D., Ph.D./M.D, M.D., or Ph.D./DVM, with a record of peer-reviewed publications.
• Molecular biology, protein expression, purification, crystallization, and functionalization.
• Generation and characterization of monoclonal antibodies for diagnostic and therapeutic purposes.
• In vitro methods for assessing immunological responses, particularly antibody assays (such as ELISA, isolation/depletion of antigen-specific antibodies, viral neutralization assays, etc.), T cell response and toxicity assays.
• In vivo immunization and/or tumor investigations, specifically murine (transgenic and humanized), rabbit and NHP models.
• Ability to design and execute laboratory experiments, critically interpret experimental results, and present data in a clear and concise manner
• Ability to participate in the preparation of grant applications, scientific publications and investigational new drug applications.
• Good organization, excellent writing and oral communication, and ability to work in an interdisciplinary team are essential.

Additional information:

• For more information about Dr. Javier Gordon Ogembo's lab, please visit here.
• The estimated pay scale represents the typical [salary/hourly] range City of Hope reasonably expects to pay for this position, with offers determined based on several factors which may include, but not be limited to, the candidate's experience, expertise, skills, education, job scope, training, internal equity, geography/market, etc. This pay scale is subject to change from time to time.
• As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

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