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Single Cell Epigenomics and Transcriptomics of Human Brain and RNA Therapeutics

University of California, San Diego
San Diego, California
60K+ depending on qualification and experience
Closing date
Mar 4, 2023

Available immediately for highly motivated recent PHDs and/or MDs with strong training in any of the following disciplines: biochemistry, bioinformatics, immunology, neuroscience, molecular and cell biology, virology, medicinal chemistry or chemical biology to participate in any of the following projects involving multidisciplinary teams of clinicians and basic science investigators: (a) innovative single-cell studies to generate cellular part list for human brain regions illuminating novel insights into transcriptomic and epigenetic landscapes of CNS and how they are altered by viruses and drugs; (b) designing and evaluating new RNA vaccines and gene therapies; (c) investigate RNA biology mechanisms in immune functions altered by RNA viruses and cancer; (d) identify epitranscriptomics roles in regulating cancer and host-pathogen interactions; (e) develop and employ human stem cell derived 3D organoids and stem cell based disease models; (f) structure-based design and synthesis of new drug candidates, lipid nanoparticles, to treat cancer and viral infections. Technologies employed in our projects include CRISPR, RNAi, RNA and genes delivery, single cell genomics (scRNA-seq and scATAC-seq), spatial transcriptomics, bioinformatics, in vitro and in vivo models, computational drug design and synthesis, and biochemical kinetics assays to analyze drug activities. Strong publication record and training to perform independent research are required for further consideration. We hsighly value and encourage applicants from underrepresented minority groups. For examples of our multidisciplinary work and technologies used in our work, see and . Successful Candidates will be part of a stimulating and collaborative scientific environment with cutting-edge instrumentation and facilities. Applicants should send CV and names and addresses of three references to Administrative Coordinator, Rana Laboratory, Division of Genetics, Program in Immunology, Moores Cancer Center, Institute for Genomic Medicine, and Center for Drug Discovery Innovation, University of California San Diego, La Jolla, California, USA.


The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to gender, race, color, religion, sex, national origin, disability, age or protected veteran's status.


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