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Discovery Fellow, Mechanisms of Tumor Resistance (Biochemistry)

Cambridge, Massachusetts, United States
Closing date
Feb 10, 2023

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Life Sciences, Biochemistry
Position Type
Full Time
Organization Type

Job Details

Job Description

1 purpose - to reimagine medicine! Come join the Novartis Institutes for Biomedical Research (NIBR) as a Discovery Postdoctoral Fellow and contribute to tackling one of the most pressing challenges in Oncology - tumor resistance.

NIBR is the innovation engine of Novartis. We collaborate across scientific and organizational boundaries, with a focus on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients.

Our Oncology Team in Cambridge, Massachusetts is seeking highly motivated and team-oriented Postdoctoral Fellows to form a Postdoctoral Hub that will focus on tumor plasticity and mechanisms of resistance to Ras/Raf/MAPK pathway therapies. The projects will combine multiple lines of investigation, including biochemical and cellular studies, genetic screening, in vivo models, tumor microenvironment analysis, molecular biology and transcriptomic profiling.

Candidates will join a vibrant scientific community and collaborate with experts across subject areas and platforms including data-science, translational oncology, and drug discovery. This is an outstanding opportunity to conduct innovative, interdisciplinary research expected to be published in leading journals. The postdoctoral term is up to 4 years and will be under direct mentorship of Drs. Shiva Malek, Vesselina Cooke, Carmine Fedele, Saskia Brachmann, Adelajda Hadzipasic, and Erin Artin.

We are seeking a postdoctoral fellow with experience in developing biochemical, biophysical and/or cellular assays for profiling protein-protein and protein-small molecule interactions, and with a record of accomplishment in investigating mechanistic biochemistry and pathway biology.

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What You'll Bring to the Role:

* Ph.D. in Biochemistry, Cellular Biology, or related subject area.
* Expertise with in vitro assay development (biochemical or in cell assays) across a variety of assay types.
* Ability to generate testable hypothesis and solve challenging interdisciplinary problems.
* Familiarity with analyzing, interpreting, and presenting large datasets in a clear and concise manner.
* Knowledge of chemical biology, structural biology, and/or high-throughput workflows is a plus.
* Excellent collaborator and team member, with effective communication and interpersonal skills.
* Eagerness to embrace opportunities to learn.

How to apply:

* Please submit a cover letter and CV
* One-page description of your research accomplishments to date
* Contact information for 2 references

For more information about our postdoctoral program, please visit:

Why Novartis?

766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.

We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!

Imagine what you could do here at Novartis!

Commitment to Diversity & Inclusion:

Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

Accessibility and Reasonable Accommodations:

Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please send an e-mail to tas.n [email protected] or call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

The pay rate for this position at commencement of employment is expected to be $70,000 per year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: #PDX


At Novartis, we are reimagining medicine.

Our purpose is to reimagine medicine to improve and extend people's lives. We use innovative science and technology to address some of society's most challenging healthcare issues. We discover and develop breakthrough treatments and find new ways to deliver them to as many people as possible.

Novartis has one of the industry’s most competitive pipelines. Many of these projects, which include new molecular entities as well as additional indications and different formulations for marketed products, are for medicines that could significantly advance treatment standards for patients worldwide.

We have entered an exciting era in health and biomedical innovation. Powered by our incredible colleagues, supported by our flexible-hybrid working model, new AI powered learning, personal growth and career platform and a refreshed commitment to diversity, equity & inclusion, we are well-poised to help lead this transformative moment for our industry and for ourselves. Join Us!

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