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Principal Scientist, LCMS Biomeasures

Employer
Pfizer
Location
Andover, Massachusetts
Salary
Competitive
Closing date
Feb 9, 2023

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Discipline
Health Sciences, Drug Development
Position Type
Full Time
Job Type
Staff Scientist
Organization Type
Pharma
ROLE DESCRIPTION

The biomeasures LCMS group in Biomedicine Andover is looking for an accomplished expert in targeted proteomics or protein LCMS bioanalysis to lead bioanalytical projects supporting transformative mRNA/LNP and biotherapeutics sciences. The principal scientist will determine the analytical biomeasure strategy, translate project needs into biomeasure assay solution and be a mentor or supervisor to other staff. The principal scientist will deploy her/his technical expertise in the lab by developing advanced protein mass spectrometry and targeted proteomics assays. These assays will then be used to measure concentrations and turnover of targets of biotherapeutics in a variety of biological matrices as well as transgene protein expression from mRNA-LNP therapies. The successful applicant will apply sample preparation and enrichment techniques including antibody-free approaches, protein and peptide immunoaffinity in conjunction with LCMS-based detection using high resolution and triple quadrupole MS. The measured parameters from preclinical studies or human specimens are input parameters to mechanistic models supporting target evaluation, dose, or efficacy projections. The successful candidate will join a state-of-the-art laboratory with deep expertise in protein quantification by mass spectrometry and is expected to build strong collaborative partnerships, both within and outside the group. This position requires strong bioanalytical expertise, solid background in protein biochemistry, expertise in immunoanalytical procedures and triple quadrupole and high-resolution quantitative mass spectrometry. This position will work in project teams and interacts closely with the full spectrum of team members including modelling & simulation experts, project leads, biologists, and protein engineers.

ROLE RESPONSIBILITIES

• Responsible for determining the analytical biomeasure strategy, translate project needs into biomeasure assay solution.

• As a skilled mentor directly collaborate with other expert or junior group members on projects or technology advancement.

• Responsible for the development, qualification and implementation of transgene protein, target biomeasure and pharmacodynamic biomarker assays using mass spectrometry in support of discovery and translational projects.

• As a strong collaborator and based on demonstrated project impact, develop deep partnerships in a matrix environment, influencing project strategies.

• Participate or lead in technology development and implementation by exploring novel concepts and innovative workflows to expand the group's biomarker bioanalytical capabilities.

• Participate in all phases of mass spectrometry laboratory operations including technology evaluations, the development of sample preparation and separation methods, data analysis, interpretation, reporting and follow up discussions with the project teams on utilizing the data in appropriate decision making.

• Ensure all tasks and responsibilities are carried out according to scientific and ethical standards e.g. responsible for electronic notebook record keeping; QC and peer review of data and reports.

• Publications in peer-reviewed scientific journals and external / internal presentations.

BASIC QUALIFICATIONS

• Qualified applicants hold a Ph.D. and have 5-8 years of relevant post-doctoral experience ideally at least partially in an industry setting or related degree with equivalent years of experience, ideally mostly in industry.

• Expertise in development, characterization, and implementation of biomarker assays based on quantitative protein mass spectrometry for drug development.

• Experience and knowledge in operation of modern triple quadrupole, time-of-flight and ion trap/orbitrap mass spectrometers and associated control and data analysis software systems.

• Knowledge and application of complex sample preparation methodologies as applied to quantitative protein mass spectrometry workflows techniques including immuno-analytical techniques and tissue preparation/tissue bioanalysis.

• Strong background in protein biochemistry.

• Strong attention to the detail, ability to multitask projects, agile to change and act decisively.

• Strong written and oral communication skills.

• Leadership communication skills.

• Highly motivated, strong scientific curiosity and interest in drug development.

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

•Lab based position requiring to perform all typical laboratory related activities

•Based in Andover

•Occasional travel to Cambridge (Kendal Square) is required, depending on project needs

Work Location Assignment:On Premise

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Relocation assistance may be available based on business needs and/or eligibility.

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Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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