Rutgers Biomedical and Health Sciences (RBHS)
Job Title: Managing Director (Organoid Development Core Facility)
School/Operating Unit: Rutgers Cancer Institute of New Jersey
Report To: Core Service Faculty Director
Through our science, our evidence-based actions, our openness, and our respect for those we serve, we will advance cancer-focused research worldwide and reduce the burden of cancer in our catchment area. By engaging with and empowering our exceptionally diverse populations, and addressing their questions and fears, we will engender hope for cancer patients and their families and play a critical role in strengthening the fabric of our communities by gaining and protecting their trust and providing access to the outstanding oncology care each person deserves.
Our mission is to accelerate scientific discovery focused on understanding cancer, innovating cancer treatment, and improving cancer prevention; to provide outstanding, novel, and compassionate patient care; to provide evidence-based and culturally informed education to physicians, nurses, researchers, staff, and the community; and to achieve cancer health equity in our state through outreach to and engagement of our extraordinarily diverse communities.
Curiosity and Discovery: encouraging an environment of continuous inquiry, creativity, and innovation to generate new knowledge
Integrity: earning the trust of those we serve and each other through honesty, transparency, accountability, and continuous reflection
Collaboration: approaching all opportunities with an understanding that together we are better and can achieve more; promoting and maintaining an environment of teamwork and shared knowledge
Cultivating Diversity: making conscientious efforts in all we do to ensure that our leadership, scientists, clinicians, supporting staff, and trainees reflect the rich diversity of the state of New Jersey and the patient populations and communities we serve
Respect and Caring: consistently demonstrating caring, compassion, and respect through our words and actions Perseverance: maintaining an unwavering commitment to our mission; embracing change, overcoming obstacles, and creating and recreating the path to achieve our goals
SUMMARY: The primary purpose of this position is to perform specialized research relative to the operation and management of the organoid core facility, utilizing three-dimensional culture techniques to maintain patient-derived cells, perform drug testing studies in optimized protocols, and support the development 3-D cultures for basic researchers throughout Rutgers. The Managing Director will support independent PI efforts to examine the effects of targeted therapy on cellular pathways in organoids and xenografts and perform drug testing and assay development experiments and laboratory techniques of a specialized nature under direct supervision of the Faculty Director. The Managing Director will manage a research technician on basic laboratory functions of organoid cultures. The Managing Director will assist with the preparation of grant applications, reports and scientific manuscripts as requested.
The Organoid Facility is a developing Shared Resource with planned support from the NCI’s Cancer Center Support Grant led by the Rutgers Cancer Institute of New Jersey and our consortium partner at Princeton University. The Managing Director will work with the Faculty Director to meet the NCI’s expectations and track collaborations, publications, grant use while supporting a variety of basic, translational, and clinical research project
ESSENTIAL DUTIES AND RESPONSIBILITIES include the following. Other duties may be assigned.
- Leads research and clinical technical operations relative to ongoing investigatory activities of the organoid development shared resources facility.
- Directs a research technician in basic laboratory functions related to the organoid development, including media preparation, equipment maintenance, etc.
- Performs experiments independently, followed by appropriate reports, recommendations, and conclusions.
- Develops performance standards of the organoid assays, selection of methodology and instrumentation and coordination of the analytical, biochemical, physiology and instrumentation functions with the clinical and research areas to ensure conformance with the goals and objectives of the Core service and center studies.
- Conducts a continuous program of research and assay development regarding organoid generation and maintenance, constantly evaluates existing procedures where required to keep methodology and procedures current.
- Supports the development of grants and research publications as co-investigator and co-author.
- Generates, compiles, and presents statistical data with appropriate conclusions, recommendations, etc. pertinent to research and service activities.
- As required, assists in the implementation of the programs and projects in special areas of interest to the department.
- Manages daily activities of the shared resource, which includes conducting experiments and developing laboratory procedures required for its function; manages a technical group and plans effective strategies to complete a variety of cell and molecular biology-related projects simultaneously.
- Implements and approves all standard operating procedures (SOPs) and reviews schedules for laboratory assays.
- Responsible for the business administration of the shared resource, including developing budgets, tracking expenses, invoicing and billing for services, and tracking of usage for CCSG reporting.
- Develops and calculates actual-cost-rates for services and assays, coordinates with finance and shared resource administration to develop SKUs and charge guides.
- Manages staff development and training, including goal setting and performance reviews.
- Understands and adheres to Rutgers’ compliance standards as they appear in RBHS’s Corporate Compliance Policy, Code of Conduct and Conflict of Interest Policy. Understands, demonstrates and models the Rutgers Cancer Institute of New Jersey core values.
- Keeps abreast of all pertinent federal, state and Rutgers’s compliance standards as they appear in RBHS’s Corporate Compliance Policy, Code of Conduct and Interest policy.
- Acts as a role model for corporate integrity, customer service and improved quality.
- Performs other related duties as assigned.
JOB REQUIREMENTS: To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed must be representative of the knowledge, skills, minimum education, training, licensure, experience, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Ph.D. Degree or equivalent in Cancer Biology or Pharmacology and 5 years of experience with organoid models is required. Research experience in examining signaling pathways regulating gene expression in tumor and/or stem cells is preferred. Expertise in three-dimensional cell culture, stem cell culture, targeted therapy, pharmacological assays, protein purification, primary tumor graft models or genetically engineered mouse models, and PCR are highly preferred. Proficiency in relevant statistical analysis of data is required. Effective oral and written communications skills. Must be computer literate with proficiency and working knowledge of database and reporting tools such as Microsoft Word, Excel and PowerPoint.
PHYSICAL DEMANDS: Standing, sitting, walking, talking and hearing. No special vision requirements. Lifting up to 25 lbs.
WORK ENVIRONMENT: Laboratory environment. Moderate noise. Exposure to blood, excrement, antineoplastic drugs, and exposure to infectious or communicable diseases. Universal precautions are mandatory. Exposure to hazardous chemicals.