Dr. Kapil N. Bhalla is currently seeking a Research Scientist who will be responsible for conducting research in his NIH-funded laboratory. The focus of the basic and translational research in this laboratory includes the biology and developmental therapeutics related to epigenetic mechanisms involving histone deacetylases, methyltransferases and demethylases, BET proteins. Additional focus is on chaperone biology of heat shock proteins and their cancer relevant client proteins regulating cell growth, differentiation and survival of the human leukemia stem/progenitor cells. The qualified candidate must possess a Ph.D. in Biology, Biological Sciences, Life Sciences or related field and a keen interest and experience in cancer research. The candidate must have completed at least a 3-year Post-doctoral fellowship in an area relevant to the focus of research in Dr. Bhalla's laboratory. The qualified candidate must have the ability to troubleshoot in the design and conduct of the laboratory studies. Experience in molecular studies involving gene transfection, analysis of gene expression through QPCR, microarrays, immunoblots and flow cytometry, as well as experience in chromatin immunoprecipitation studies, evaluation of protein biochemistry with 2D gels and the yeast-two-hybrid system, and tissue culture techniques is required. Experience in the ability to utilize CRISPR technology for gene editing and to conduct CRISPR screens, as well as to utilize confocal microscopy for molecular imaging is highly desired. Experience in xenograft and genetically-engineered animal models of cancer and/or leukemia, and confocal microscopy is also desired. An outstanding research environment and guidance, new laboratory and core facilities are provided.
Research Design and implementation
Plans, organizes, coordinates, directs and conducts scientific research projects. Develops and maintains standard procedures and protocols to ensure the quality and integrity of the procedures performed. Coordinates with other investigators to provide appropriate support on analytical techniques. Maintains detailed experimental records, evaluates resulting research data, and presents findings to physicians and/or professional groups.
Analyzes and evaluates research data and revises techniques and approaches to work problems. Works with the Principal Investigator on projects in the area of molecular biomarker development in leukemia/lymphoma biology. Participates in adopting new bioinformatics analyses and learning new bioinformatics skills to enhance research efforts.
Supervises and mentors trainees and other laboratory personnel with respect to proper laboratory techniques, the use of laboratory equipment and safety procedures. Publications/Manuscripts and Presentations. Contributes to manuscripts and prepares documents for publication. Compiles, writes, and submits reports to superior. Presents results at national meetings.
Required: Master's degree in one of the natural sciences or related field.
Required: Four years of experience in experimental or scientific work. With PhD, no experience required. With Medical degree, two years of experience in experimental or scientific work.
Preferred: With PhD and completed at least a 3 year Post-doctoral fellowship in an area relevant to the focus of research in Dr. Bhalla's laboratory.
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