Postdoctoral Fellowship in Stem Cell Biology and Developmental Neuroscience

We are using human stem cell derived excitatory and inhibitory neurons, astrocytes, microglia, and neurovascular-like cells in mono-and mixed carpet cultures, as well as organoid differentiations, as tools for the study of gene-gene and gene-environment interactions in neuropsychiatric disease. Illnesses of particular interest include schizophrenia, autism, and epilepsy, with some emphasis on mitochondrial influences on symptom penetrance. We also have an emphasis on collaborative studies with labs in the CHOP/UPenn community on a variety of topics such as blood brain barrier/neuroimmunology, glioblastoma treatment, circadian/metabolic influences on neural development, HIV, and traumatic brain injury.

This position requires a strong desire to learn about forebrain development in relation to neuropsychiatric disease in a highly collaborative environment. Cell culture experience, especially with mouse or human ES or IPS cells, is strongly preferred. Additional experience in developmental neuroscience and basic molecular biology (i.e. basic RNA-seq informatics, RT-PCR, basic cloning, CRISPR-CAS or other gene editing) is also preferred.