Postdoctoral Researcher (Single Cell)

We are seeking a highly-motivated Postdoctoral Scholar to work with researchers in the CEDAR program at OHSU. CEDAR is focused on detecting and treating lethal cancers at the earliest stage. You will work closely with Dr. Hisham Mohammed and other CEDAR researchers to develop key questions on cancer initiation and progression in breast cancer. You will apply novel single-cell epigenetics, multi-omics and proteomics tools to understand how underlying genetic and epigenetic variability drives tumor evolution.

As a Postdoctoral Scholar you will address the following general themes:

• Investigate fundamental biological processes of cancer initiation and progression. Current interests include deciphering the role of hormone receptors and deep spatially oriented proteomic and transcriptomic analysis of patient tumors to determine therapeutic opportunities. CEDAR researchers have unique access to longitudinal clinical samples and trials to test emerging hypotheses.
• Develop existing or novel technologies with the aim of accurately monitoring biological processes at a single-cell proteomic, transcriptomic and epigenetic level. The team has previously developed proteomics (RIME), single-cell and multi-omic technologies (Mohammed et al, Argelaut et al). Of particular interest is integrating tumor spatial information with single-cell transcriptomics, epigenetics (methylation, chromatin accessibility) and proteomics. This position will leverage unique partnerships with industry innovators.

CEDAR is committed to increasing the diversity of the campus community. We at CEDAR are dedicated to promoting inclusion and multiculturalism to build a successful organization by having outstanding researchers of diverse backgrounds work together on multiple projects. We encourage high-risk, high-reward research projects because defeating cancer requires unproven, out-of-the-box thinking. Our research is milestone driven to ensure that each project is fulfilling its stated goals.

CEDAR funds its own research projects, expediting the process of discovery. Our research is milestone-driven to ensure that each project is fulfilling its stated goals. CEDAR offers a unique opportunity for outstanding, driven, and creative postdoctoral fellows to perform cutting edge and high-risk research, ranging from understanding basic cancer biology to developing novel technologies to aid detection. Our focus on early detection requires novel approaches to reliably identify small/rare signals in diverse data types, with an emphasis on minimally invasive sampling techniques.