Columbia University Irving Medical Center’s Department of Molecular Pharmacology and Therapeutics is in the Vagelos College of Physicians and Surgeons and is focused on advancing biomedical research through the study of molecular genetics, chemical biology, and structural biology to identify specific and novel targets to modify the function of living systems and impact disease response. The Department bridges basic and clinical science, and the research of faculty members span such diverse problems as the identification of molecular signals that determine whether a cell lives or dies to the discovery of new drugs that control cardiac rhythm in heart disease; the use of inducible pluripotent stems as drug screening platforms; the physiology and pharmacology of pain pathways; mechanistic studies of schizophrenia; x-ray crystallography of GABAB receptors and pharmacology and physiology of GABAA receptors.
The Concepcion Laboratory in the Department of Molecular Pharmacology and Therapeutics seeks a full-time Postdoctoral Research Scientist to join a growing research team focused on epigenetic deregulation in lung cancer. Our laboratory is interested in understanding how alterations in chromatin state shape tumor cell fate throughout tumor evolution. Areas of investigation include: 1) understanding how mutations in chromatin regulators alter the chromatin landscape to facilitate malignant transformation; 2) investigating gene regulatory programs co-opted by cancer cells throughout tumor progression; and 3) identifying dependencies and targetable features of lung cancers harboring specific mutations in chromatin regulators.
Minimum Degree Required
- Ph.D., MD, or equivalent doctoral degree
- Applicants must have a Ph.D., M.D., or equivalent degree
- Experience in molecular and cellular biology, 2D and organoid culture systems, generation and analyses of mouse models of cancer, -omic technologies, and bioinformatics.
- Excellent scientific and interpersonal communication skills.
- Highly organized Team player