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Research Assistant II -CRISPR and 3D Organoids

Baylor College of Medicine
Houston, Texas
Closing date
Feb 1, 2023

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Other, Other
Position Type
Full Time
Job Type
Research Scientist
Organization Type
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Full-time research staff position in the Cell-Based Assay Screening Service (C-BASS), Advanced Technology Core for Baylor College of Medicine. Responsibilities will be divided between conducting lab bench collaborative research experiments and projects as services for faculty customer users of the Core, assist with consultation and up-front design of experiments with core users, analysis and reporting data from projects to core users, contributing to technical writing of Core user grants and publications and performing research on the development of new innovative technologies and methods. Other responsibilities include user project entry into the iLab billing system to ensure collection of charge-backs and assistance with yearly progress reports.

To know more about the lab, please click on the link below.

Job Duties

  • Perform complex lab experiments in an independent manner using standard operation procedures for functional genomic screening and CRISPR genetic editing projects.
  • Communicate with investigator core users during the course of the project and assist, in consultation with core user and Core Director, on decision making steps of projects.
  • Manage and analyze data using standard methods and the report data and results to the Core user and Technical Core Director.
  • Participate in projects to develop new technologies and methods for the Core.
  • Perform some routine smaller scale lab duties such as preparation and distribution of shRNA and CRISPR sgRNA clones and libraries, cell culturing, freezing and inventory of gene edited cloned cell lines.
  • Assist the core director with invoicing core users, tracking project requests, ordering and inventory of supplies, equipment maintenance and preparing information for submitting Core annual progress reports.
  • Assist the Advanced In Vivo models core with experiments using patient-derived xenograft models grown as 3D orgnanoids or on the chicken egg chorioallantoic membrane.
  • Experiments will entail 3D organoid culture and xenograft engraftment on the CAM model, 3D organoid manipulation and tumor dissection for processing, tissue and/or organoid DNA isolation and analysis, qPCR setup and analysis, and detailed experimental recording. R & D experiments coupling CRISPR gene editing and 3D organoid technologies will be conducted as time permits.

Minimum Qualifications

  • Bachelor's degree in a Basic Science or a related field.
  • Three years of relevant experience.

Preferred Qualifications

  • A bachelor's degree in relevant area of biological sciences with 3 years of bench research experience related to technologies of the C-BASS and AIM Cores.
  • A master's degree in relevant area is preferred

Baylor College of Medicine requires employees to be fully vaccinated -subject to approved exemptions-against vaccine-preventable diseases including, but not limited to, COVID-19 and influenza.

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.


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