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Senior Scientist - Tumor Biology, Fitness and Evolution

La Jolla, California
Closing date
Jan 27, 2023

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Life Sciences, Biology, Health Sciences, Drug Development
Position Type
Full Time
Job Type
Senior Scientist
Organization Type
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Why Patients Need You

Despite significant progress in understanding the events that contribute to tumor development and malignancy in the past 30 years, the survival rates for many cancers have only shown modest improvement. Pfizer is committed to bringing forward new transformative medicines that will change patients' lives, with Research and Development at the heart of fulfilling this purpose. Whether you are in discovery, ensuring drug safety and efficacy or supporting clinical trials, you will be a key contributor to our mission of bringing best in class medicines to patients around the world.

Oncology Research and Development (ORD) is working to change the trajectory of cancer by translating breakthrough discoveries in cancer research into the best medicines imaginable for patients. Our Tumor Biology Tumor Fitness and Evolution group supports small molecule cancer drug discovery and development all the way from target discovery and validation through early clinical development.

What You Will Achieve

As a member of our Tumor Fitness and Evolution Discovery Biology team, you will support lab-based research projects to identify and validate novel druggable targets. As you support projects, you will gain exposure to the larger Pfizer organization, learn various cutting-edge techniques, contribute to collaborations with cross-functional teams, and be a part of a culture that embraces scientific excellence and personal development.

How You Will Achieve It

  • Maintain and establish various mammalian cell lines and organoids used to credential new targets
  • Perform cellular and biochemical assays to evaluate the outcome of various genetic or chemical perturbations
  • Analyze, interpret, and present data to the team and/or organization
  • Troubleshoot experiments in a timely manner
  • Learn and apply new techniques to support ongoing drug discovery efforts
  • Interface with project teams, develop research plans, contribute in-lab, manage Contract Research Organizations (CROs), and mentor junior colleagues


Must Have
  • PhD degree in Molecular/Cellular Biology, with 2+ years of post-doc experience in the field of tumor biology.
  • Track record of successful contribution to research projects, leading to project advancement and/or peer reviewed publications
  • Expertise in routine molecular and cellular techniques; for example: qRT-PCR, Western blotting, ELISA, ChIP, cloning, stable cell line generation
  • Familiarity with human organoid cultures, CRISPR-mediated gene editing, NGS sample prep, plate-based assays, NanoBRET/NanoBiT, and/or flow cytometry
  • Strong communication skills--verbal and written and strong presentation skills

Nice To Have

  • Knowledge in the field of hormone-dependent cancers
  • Experience querying oncology databases, such as cBioPortal, TCGA, and DepMap
  • Related industryR&D experience

Relocation support available

Work Location Assignment:On Premise


The annual base salary for this position ranges from $82,400.00 to $137,300.00. In addition, this position offers an annual bonus with a target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. Benefits offered include a retirement savings plan, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans. Salary range does not apply to the Tampa, FL location.

Relocation assistance may be available based on business needs and/or eligibility.


Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development
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