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Expert Downstream Scientist - mRNA purification

Rockville, Maryland
Closing date
Dec 1, 2022

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Health Sciences, Drug Development
Job Type
Staff Scientist
Organization Type
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Are you energized by a challenging role in biology, where scientific demand is driving team growth? If so, this Expert Scientist role would be a great opportunity to consider.

The Nucleic Acids Vaccines Center of Excellence global team (Technical Research & Development, GSK Vaccines) is seeking an enthusiastic, experienced, and motivated Scientist with a strong understanding and experience in downstream process development and nucleic acid research. Located in Rockville, MD, the position will contribute to the success of the GSK messenger RNA (mRNA) vaccine platform.

Working in a highly collaborative environment, the successful candidate will:

  • Drive development & optimization of a clinical & commercial manufacturing processes for the purification of mRNA and DNA.
  • Independently design and execute laboratory experiments.
  • Partner with diverse team members from various functions, multiple countries and members at various levels in organization.
  • Benchmark specific technologies in own functional area to bring technology to state of the art.
  • Solve complex problems through analytical thinking to identify and understand alternatives using knowledge gained through formal education, experience and sound judgment.
  • Prepare oral and written reports to communicate scientific findings and to support project documentation and CMC submissions.
  • Comply with data integrity requirements for laboratory work.

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:
  • Degree in Biochemistry, Molecular Biology, Chemical Engineering, Biotechnology, Bioengineering, or a related scientific field.
  • MS with 6+ years of experience or PhD with 2+ years of experience.
  • Relevant specific expertise in mRNA purification or very broad & deep expert-level experience & understanding of purification of biomolecules.
  • Experience with different purification techniques such as chromatography and tangential flow filtration (TFF) and associated instrumentation such as Akta chromatography systems and Unicorn software.
  • Experience with preparative HPLC.
  • Experience with bioanalytical assays associated with purification processes, such as SDS-PAGE, Western blotting, HPLC, etc.
  • Experience in research and development in a Biopharmaceutical industry or government laboratory setting is a must.

Preferred Qualifications:

If you have the following characteristics, it would be a plus:
  • Understanding of purification of biologics, specifically large size mRNA, including process scale-up.
  • Strong hands-on experience with a wide range of purification techniques for large nucleic acid molecules including affinity capture, ion exchange and hydrophobic interactions.
  • Experience and understanding of nucleic acid analytical technologies.
  • Understanding of Quality by Design and the development of a process control strategy.
  • Have understanding of experimental design and be able to independently execute laboratory experiments.
  • Design and execute DOE studies & high-throughput screen for purification process improvements and advancements including parameter optimization, scale-up, process window determination and process capability evaluation.
  • Communicate effectively with regular verbal and formal updates to project teams and management.
  • Knowledge of technology transfer and GMP manufacturing.
  • Be able to rapidly acquire project understanding and apply professional knowledge to project improvement.
  • Demonstrated ability to efficiently work in a fast paced and fluid environment, changes in priority and timeline restrictions.
  • Proficiency in English is a must.

Why GSK?

Our values and expectationsare at the heart of everything we do and form an important part of our culture.

These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
  • Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigor and risk.
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Continuously looking for opportunities to learn, build skills and share learning.
  • Sustaining energy and well-being.
  • Building strong relationships and collaboration, honest and open conversations.
  • Budgeting and cost-consciousness.



*This is a job description to aide in the job posting, but does not include all job evaluation details.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve.

GSK has made the decision to require all US employees to be fully vaccinated against COVID-19, where allowed by state or local law and where vaccine supply is readily available. The only exceptions to this requirement are employees who are approved for an accommodation for religious, medical or disability-related reasons.

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