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Senior Scientist - Tumor Biology

La Jolla, California
Closing date
Jan 19, 2023

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Life Sciences, Biology, Health Sciences, Drug Development
Position Type
Full Time
Job Type
Senior Scientist
Organization Type
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Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose where we translate science and technologies into the therapies and vaccines that matter most. Whether you are in discovery, ensuring drug safety and efficacy or supporting clinical trials, you will be a key contributor to our mission of bringing best in class medicines to patients around the world.

Our Oncology Research and Development (ORD) division is working to change the trajectory of cancer by translating breakthrough discoveries in cancer research into the best medicines imaginable for patients. Our Tumor Biology Tumor Fitness and Evolution group supports small molecule cancer drug discovery and development all the way from target discovery and validation through early clinical development.


As a member of our Tumor Fitness and Evolution group, you be an integral part of our collective efforts to discover and target novel vulnerabilities and overcome acquired and adaptive resistance networks to existing small molecule therapies. You will work in a lab-based setting and carry-out molecular and cellular based assays including functional genomic studies and data analysis, employ critical thinking to design and interpret experiments and communicate research findings to project teams. As you support and champion projects, you will gain exposure to the larger Pfizer organization, learn from collaborations with cross-functional teams, lead biology efforts for portfolio and early discovery projects and be part of a culture that embraces scientific excellence and personal development.

  • Design, execute and analyze experiments to address the basic and translational biology of novel drug targets, their molecular pathways, and their connection to human disease.
  • Design, execute and analyze experiments to address the adaptive and acquired resistance nodes and networks of small molecules targeting oncogenic signaling pathways to inform mitigation strategies for these disease states.
  • Participate actively in scientific discussions and stay informed of publications in relevant areas.
  • Communicate and present research findings in small group meetings and larger project team meetings.
  • Collaborate with colleagues within the department and across departments to drive projects forward.


  • Ph.D. in Cancer Biology, Cell Biology, or a related field with at least 1-year relevant post-graduate experience in industry or academia.
  • Track record of independent research evidenced by publication in peer-reviewed journals.
  • Track record of independent research evidenced by conference presentation at internationally recognized conference series.
  • Experience with foundational Cell and Molecular Biology techniques (e.g., Construct Design, Lentiviral Generation, Stable Cell line Generation, 2D-adhered and 3D-Spehroid Proliferation assays, Western blots, QPCR).
  • Experience with functional genomic and protein interrogation methods (e.g., CRISPR, DTAG).
  • Experience querying oncology databases such as cBioportal, TCGA, DepMap
  • Experience using R-programing language for interpretation of large data sets and figure generation.
  • Research experience in areas of tumor biology, such as tumor heterogeneity, plasticity, and adaptive networks/ acquired resistance to small molecule inhibitors.
  • Strong verbal, presentation and written communication skills.

  • 2+ years of related postdoctoral and/or industry R&D experience.
  • Knowledgeable in oncogenic signaling pathways.
  • Experience working with large data set outputs including Phospho-proteome, RNA Seq, Whole Exome Seq and Single-cell data sets.

Relocation support available

Work Location Assignment:On Premise


The annual base salary for this position ranges from $82,400.00 to $137,300.00. In addition, this position offers an annual bonus with a target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. Benefits offered include a retirement savings plan, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans. Salary range does not apply to the Tampa, FL location.

Relocation assistance may be available based on business needs and/or eligibility.


Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development
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