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Research Scientist, Characterization & Mass Spectrometry

Boston, Massachusetts, United States
Closing date
Nov 29, 2022

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Health Sciences
Position Type
Full Time
Job Type
Research Scientist
Organization Type
All Industry, Pharma

Job Details

Job Description

6000! This is the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on new technologies that have the potential to help produce therapeutic breakthroughs for patients.

The Characterizations and Formulations team at NBC characterizes new therapeutic protein and cell and gene therapy candidates of various formats throughout discovery to the handover to development. Our team of motivated and highly skilled scientists from various backgrounds provide expertise in areas such as physical-chemical analytical characterization, mass spectrometry, and formulation in an international setting.

As a Research Scientist in the characterization team, you will be responsible for assisting with mass spectrometry and physical-chemical characterization of biologics during drug discovery to early drug development. You have the unique opportunity to gain experience with a wide range of biotherapeutics with chances to create significant experimental and intellectual contributions to our exciting biologics pipeline.

What you’ll be doing:
Your responsibilities include, but are not limited to:
• Execute assays for characterizing candidates using mass spectrometry at both the intact, subunit, and peptide level
• Operate and maintain instruments, perform data analysis and ELN/Genedata documentation, and author and/or review method development and technical reports
• Apply physical-chemical analytical methods for orthogonal support of MS analyses (CE-SDS, reverse phase LC, charge variant characterization)
• General understanding of analytical and biophysical characterization of therapeutic antibodies, multi-specifics, ADCs, therapeutic proteins, cell and gene therapies, and/or emerging biotherapeutic modalities
• Work in a highly interdisciplinary and collaborative environment as part of the global NBC team and contribute to data analysis and interpretation, making technical presentations, and report writing
• Interact and collaborate with colleagues in biologics across Discovery and Development organizations.

This position will be located at the Cambridge, MA site and will not have the ability to be located remotely. This position will require 0% travel as defined by the business (domestic and/ or international).

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you’ll bring to the role:
• M.S. with 1+ years or B.S. with 3+ years in chemistry, biochemistry, or related field years of biotech/biopharmaceutical industry experience
• Demonstrated expertise with hands-on experience in setting up top-down and bottom-up mass spectrometry analyses of biotherapeutics
• Demonstrated technical understanding and expertise in the field of analytical characterization of large biotherapeutic molecules
• Demonstrated scientific curiosity, problem-solving skills, and ability to design and execute experiments independently
• A great teammate who is detail-oriented, can multi-task, and has outstanding oral and written communication skills.

• Experience with Genedata Expressionist for mass spectrometry analysis is highly preferred
• Hands-on experience with CE-SDS, cIEF, reverse phase liquid chromatography, SEC, and/or other analytical assays

Commitment to Diversity & Inclusion:
Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

Accessibility and Reasonable Accommodations: The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to [email protected] call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Why Novartis?
766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.

We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!
Imagine what you could do here at Novartis!
While Novartis does not require vaccination at this time, for certain Novartis sites in the US all associates and candidates may be required to either upload an image of their COVID-19 vaccine card demonstrating proof of full vaccination for COVID-19 (or other similar evidence of vaccination) or proof of a negative COVID-19 test taken by the associate or candidate within the past seven days to enter any of our sites and/or customer office or healthcare facility, as well as prior to participating in other work related off-site meetings. Employees working in customer-facing roles must adhere to and comply with customers’ (such as hospitals, physician offices, etc.) credentialing guidelines, which may require vaccination. As required by applicable law, Novartis will consider requests for reasonable accommodation for those unable to be vaccinated. This requirement is subject to applicable state and local laws and may not be applicable to employees working in certain jurisdictions. Please send accommodation requests to Eh.occupati [email protected] .


At Novartis, we are reimagining medicine.

Our purpose is to reimagine medicine to improve and extend people's lives. We use innovative science and technology to address some of society's most challenging healthcare issues. We discover and develop breakthrough treatments and find new ways to deliver them to as many people as possible.

Novartis has one of the industry’s most competitive pipelines. Many of these projects, which include new molecular entities as well as additional indications and different formulations for marketed products, are for medicines that could significantly advance treatment standards for patients worldwide.

We have entered an exciting era in health and biomedical innovation. Powered by our incredible colleagues, supported by our flexible-hybrid working model, new AI powered learning, personal growth and career platform and a refreshed commitment to diversity, equity & inclusion, we are well-poised to help lead this transformative moment for our industry and for ourselves. Join Us!

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