The Laboratory of Dr. Gang Xin
Department of Microbial Infection and Immunity
Pelotonia Institute for Immuno-Oncology
The Ohio State University Comprehensive Cancer Center
The Ohio State University Wexner Medical Center in Columbus, Ohio is the only academic medical center in Central Ohio and ranked as one of “America’s Best Hospitals” by U.S. News and World Report for 20 consecutive years! We are committed to comprehensive patient care, high caliber research and innovative medical education for medical students, post-doctoral trainees and professional colleagues.
The OSUCCC – James is the only cancer program in the United States that features a National Cancer Institute (NCI)-designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nation’s largest public universities.
The research project is centered on the metabolic reprogramming that regulates tumor-infiltrating myeloid cells and their interplay with T cells in mouse model and in humans. The Post-Doctoral Researcher will pursue specialized research training and experience under the guidance of a scientific mentor; conducts research to characterize the immunologic and genetic basis of human cancers; develops, adopts and implements new experimental methods to achieve further characterization of various human immune cell types, their respective developmental pathways; delineates mechanisms of tumor resistance to immunotherapy, such as immune checkpoint inhibitors (ICI), identifies novel genes and examines their role in the development of immunologic approaches to disease treatment; analyzes changes in mRNA or protein expression, flow cytometric analysis, gene cloning and mutation detection; integrate cutting edge single-cell RNA sequencing and multi-parametric flow cytometry with traditional molecular biology based approaches; participates in analyzing data for reports for the purpose of grants submissions; designs and conducts pre-clinical studies using a variety of disease models in mice; trains staff, focuses efforts to generate a better understanding of resistance to ICI, to conceive and develop novel treatments/combinations and biomarkers, identify new targets for novel therapeutics, use multi-color flow cytometry, cell isolation and primary cell and tissue culture. Experience with high dimensional data analysis (e.g. single-cell RNA-Seq) is highly desirable. Previous experience working with research animals (mice), DNA/RNA/Protein isolation, purification, PCR/qPCR, Western and Northern blot techniques, training others in molecular biology techniques such as cloning, real time PCR, complex data analyses.
A Doctoral degree in an appropriate discipline is required. Previous experience working with research animals (mice), DNA/RNA/Protein isolation, purification, PCR/qPCR, Western blot techniques, molecular cloning, mammalian cell culture, flow cytometric data collection and analysis preferred. Requires successful completion of a background check; qualified candidates may be asked to complete a pre-employment physical including a drug screen.
Applicants should submit their current curriculum vitae with a publication list and the name and email contact information of three references to Gang.Xin@osumc.edu.
Qualified candidates should apply online at: https://osujoblinks.com/8mgu
The Target Hiring Range is $54,840.00 to $66,600.00. (per NIH guidelines for 2022)
The Ohio State University offers a competitive salary, outstanding benefits, participation in workshops and conferences, high quality Shared Resources, and many opportunities for continued professional development.
The Ohio State University is situated in Columbus, Ohio, which is a vibrant and international city. Columbus is located within a short flight to the entire eastern seaboard and provides a unique blend of culture, sports and activities coupled with an excellent and affordable standard living.
The Ohio State University is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation or identity, national origin, disability status, or protected veteran status.