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Ocular Research Scientist

Employer
Spark Therapeutics
Location
Philadelphia, Pennsylvania. Hybrid and remote options available for select opportunities.
Salary
Salary not provided
Closing date
Jan 19, 2023

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Discipline
Health Sciences, Drug Development
Job Type
Research Scientist
Organization Type
Pharma
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Job Details

Primary Duties

The Ocular Research Scientist is a member of the Ocular functional group within Translational Research.

He/she will be responsible for:

  • Design, execution and data analysis of in vitro and in vivo experiments to optimize pre-clinical development of ocular programs.
  • Writing of study reports, manuscripts, regulatory documents and present results at appropriate scientific meetings.
  • Initiate and oversee joint programs with external collaborators.
  • Collaborate with other Translational Research Scientists to develop pre-clinical programs from early discovery to the IND-enabling studies.
  • Maintain accurate experimental records.

Responsibilities

  • Hands-on execution of in vitro and in vivo experiments experiments to advance pipeline programs.
  • Manage in vivo studies performed by internal and external collaborators, including study design, vector construction and sourcing, intraocular injection, ocular imaging, tissue collection and dissection, target gene expression analysis, data analysis and interpretation, and preparation of final reports
  • Identify and validate new indication targets and evaluate gene expression cassettes to support both existing and new programs in the pipeline. This includes executing experiments on the bench, extensive literature review, championing product candidate development from proof of concept to IND submission, etc.
  • Prepare sample analysis reports and write parts of regulatory submissions to regulatory agencies.

Education and Experience Requirements

  • Ph.D. in relevant scientific discipline required (e.g. cell and molecular biology, biochemistry, etc.)
  • Minimum 3 years postdoctoral experience (industry experience is a plus)
  • Minimum 3 years of hands-on research experience with gene therapies targeting the eye.
  • In-depth familiarity with target lead identification/optimization using a combination of molecular, cellular and in vitro/in vivo techniques for ocular gene therapy programs.
  • Experience with delivery techniques targeting the eye (subretinal and intravitreal injections).
  • Experience with studies in laboratory animals.
  • Experience with histological analysis of tissue sections.
  • Experience with AAV vectors is required.
  • Molecular biology proficiency is required.
  • Strong publication record is a plus.
  • Extensive hands-on experience in in vivo ocular evaluations, such as pupillometry, ERG, OCT, etc.

Key Skills, Abilities, and Competencies

  • Extensive hands-on experience in techniques applicable to ocular gene therapy in animal models, such as intravitreal and subretinal injections, pupillometry, ERG, OCT, eye sample harvest etc.
  • Strong molecular analysis skills, such as RNA and protein analysis.
  • Cloning experience (vector design and construction).
  • Strong histology, immunohistochemistry and light/fluorescent microscopy skills.
  • Strong organizational skills.
  • Excellent writing and verbal communication skills.

#LI-onsite

Please be aware that Spark mandates COVID-19 vaccination of all employees regardless of work location. Accommodations may be made in accordance with applicable law.


Nearest Major Market: Philadelphia



Join the Spark Team

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable - until now.

We don't follow footsteps. We create the path.

Learn more about Spark Therapeutics and view other openings.

Company

At Spark Therapeutics, a fully integrated, commercial company committed to discovering, developing and delivering gene therapies, we challenge the inevitability of genetic diseases, including blindness, hemophilia, lysosomal storage disorders and neurodegenerative diseases.

Founded in March 2013 as a result of the technology and know-how accumulated over two decades at Children’s Hospital of Philadelphia (CHOP), our investigational therapies have the potential to provide long-lasting effects, dramatically and positively changing the lives of patients with conditions where no, or only palliative, therapies exist. Greater understanding of the human genome and genetic abnormalities have allowed our scientists to tailor investigational therapies to patients suffering from very specific genetic diseases. This approach holds great promise in developing effective treatments to a host of inherited diseases. Our initial focus is on treating orphan diseases.

Headquartered in dynamic Philadelphia, we are a diverse, experienced team united in our goal to break down barriers for people and families affected by genetic diseases. As our name suggests, our investigational, one-time therapies are designed to spark healthy biology, and deliver potentially life-altering transformation for people and families affected by genetic disease. Spark is a member of the Roche Group.

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Spark Therapeutics
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