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in vivo Senior Scientist, Tumor Biology--Translational Sciences

Employer
Pfizer
Location
La Jolla, California
Salary
Competitive
Closing date
Feb 1, 2023

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Discipline
Life Sciences, Biology, Health Sciences, Drug Development
Position Type
Full Time
Job Type
Senior Scientist
Organization Type
Pharma
Position Summary

You will join a dynamic team of scientists in our in vivo Tumor Biology group playing a leading role in using models of cancer to evaluate new drug candidates, mechanisms and targets.

As an in vivo Lead you will participate in pre-clinical drug discovery and development programs with a focus on tumor intrinsic biology related to signal transduction, targeted therapeutics and epigenetics. You will characterize and develop large and small molecules in close collaboration with partner lines as integral member of our drug discovery teams, employ and develop cutting edge in vivo mouse and human cancer models. You will provide technical and scientific expertise in in vivo Pharmacology across Oncology R&D to enable target identification, validation, prioritization and efficient drug discovery.

Key Responsibilities
  • Work within multi-functional teams to support large and small molecule drug discovery and combination therapy.
  • Design and conduct in vivo studies to evaluate and establish efficacy, PK/PD relationship, combination strategy, biomarker identification and analysis.
  • Interpretation, presentation and documentation of experiments within an electronic lab notebook, as well as preparation of reports.
  • Written and verbal presentation of results within a multidisciplinary team environment.
  • Develop and characterize new in vivo mouse models, including syngeneic tumor and genetically engineered mouse (GEM) models, to study biologic mechanisms and support exploration of novel therapies.
  • Publication of results in scientific peer-reviewed journals and presentations at internal, national, and international meetings.


Basic Qualifications
  • Ph.D. in Cancer Biology, Immunology or a related discipline, or MS degree in a related discipline and a minimum of 8 years relevant industry experience
  • Experience in in vivo pharmacology and experience with animal models of human cancers
  • Hands on in vivo skills (e.g.,: IV, PO dosing, blood/tissue collection, tumor implantation) and ex vivo skills (flow cytometry, western blot, ELISA).
  • Experience leading a small team
  • Current knowledge of oncology research, drug discovery and development, with emphasis on drug resistance.
  • Experience following novel scientific or technological developments, and implementing them in the laboratory.
  • Strong communication skills--written, verbal and presentation
  • Proficiency with all common office and scientific software
  • Strong ability to multi-task and work productively in a fast-paced, highly collaborative, and diverse team environment
  • Must be willing and able to work after hours as needed to ensure study integrity


Desired Qualifications
  • Strong publication track record or evidence of equivalent achievement in industry
  • Experience with GEMM and humanized models


Relocation support available

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The annual base salary for this position ranges from $82,400.00 to $137,300.00. In addition, this position offers an annual bonus with a target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. Benefits offered include a retirement savings plan, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans. Salary range does not apply to the Tampa, FL location.

Relocation assistance may be available based on business needs and/or eligibility.

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Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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