The Molecular NeuroTherapeutics Laboratory directed by Dr. Tsuneya Ikezu MD., PhD, is seeking for applications from qualified postdoc candidates with expertise in neuroscience and molecular biology for the translational studies of neurologic disorders. The two positions available are i) To investigate the therapeutic efficacy for suppressing tau pathology using antisense oligonucleotide with human iPSC cell line and organoid platform, ii) To investigate the pathological function of extracellular vesicles (EV) using genetically modified mouse strains and human iPSC platform.
Dr. Ikezu’s laboratory is recognized as a pioneer in the field of Neuro-EV and its role in the progression of neurodegenerative diseases including AD and front temporal dementia. His lab is interested in investigating the spread mechanism of pathological aggregated protein tau and a future therapeutic target of AD, frontotemporal dementia, or aging process. The research will be based at the brand-new lab at Department of Neuroscience, Mayo Clinic Florida, supported by cutting-edge instruments as well as core facilities in Mayo institute.
Ikezu lab has connected with many prestigious collaborators in the world to enhance research activity and acquire cutting edge knowledge. This position will work in a highly collaborative environment, focusing on identification of tau aggregation and spread mechanism and developing the drug.
Each applicant must possess an advanced degree (Ph.D.) in a relevant field with less than 5 years of postdoc experiences. The ideal candidates may have expertise in animal models of neurodegenerative diseases, animal surgeries, biochemistry, molecular biology, iPSC/organoid system, or confocal imaging analysis. Basic computer and math skills for the data analysis is a must. The ideal candidates also should be team players with high scientific standards and communication skills, and have ability to work in an interactive, fast-paced environment.
The accepted candidate will be trained to work independently in animal models of neurodegenerative disorders, or molecular engineering. They are expected to keep records and data of all scientific experiments according to established procedures, occasionally supervise students, act as a source of information and advice to other members of the group on scientific protocols and experimental techniques. They will have opportunities to draft technical reports, manuscripts for scientific journals, and present work internally and externally as needed for their career development.
The following links provide more information about the laboratory and institution:
Department of Neuroscience, Mayo Clinic Florida: https://www.mayo.edu/research/departments-divisions/department-neuroscience-florida/overview
To inquire, please send the following files to ikezu.tsuneya(at)mayo.edu: Curriculum vitae (including publication list), a statement of research interest including brief description of past work, and contact information of three references.