Postdoctoral Fellow: Mass Spectrometry Based Proteomics for Systems-Wide Protein Turnover Analysis

ROLE SUMMARY

An exciting postdoc position is available in the Biomedicine Design department at Pfizer, Andover, MA for a highly motivated and driven PhD graduate with solid expertise in advanced mass spectrometry-based proteomics and associated bioinformatics tools. This role provides unique opportunities for development of novel and innovative mass spectrometry assays for large scale measurement of protein physiological turnover in human and no-human species.

The successful applicant will develop and implement different sample preparation strategies from various tissue and biofluid matrices. Also, development of novel and intelligent targeted and non-targeted high resolution mass spectrometry methods and utilizing MS database search engine tools for protein identification and turnover measurement are in the scope of the role. High impact publication in top tier journals is expected. Candidate will work with bioinformatics and translational modeling and simulation experts and has the opportunity to become familiar with biormarkers and biomeasures support in drug development. This position requires solid technical expertise in high resolution LC-MS/MS, associated samples preparation and proteomics data analysis.

ROLE RESPONSIBILITIES

• Responsible for the development of samples preparation techniques from various matrices for LC-MS/MS analysis of proteome turnover
  
• Proactive engagement with the literature to use cutting edge science for novel and innovative methods to overcome challenges facing the project
  
• As a strong collaborator seeks guides and communicates with colleagues and advisors for timely achievements of the goals and milestones
  
• Uses bioinformatics and software tools for data analysis, interpretation and classification
  
• Providing periodic progress reports and presenting at internal and external conferences or meetings and publishing at top tier journals
  

QUALIFICATIONS

• Ph.D. in chemistry, biochemistry or related disciplines is required
  
• Expertise in development and implementation of assays based on protein mass spectrometry
  
• Experience and knowledge in operation of modern high resolution ion trap/orbitrap and triple quadrupole mass spectrometers and associated control and data analysis software systems
  
• Knowledge and application of complex sample preparation methodologies as applied to quantitative protein mass spectrometry workflows techniques including immuno-analytical techniques and tissue preparation/tissue bioanalysis
  
• Good level of expertise in the relevant bioinformatics tools and software for mass spectrometry data analysis and interpretation
  

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

• Lab based position requiring performing all typical laboratory related activities
  
• Occasional travel to Cambridge (Kendal Square) is required, depending on project needs
  

OTHER JOB DETAILS

Eligible for Relocation Assistance

Must have Work Authorization in the US

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Relocation assistance may be available based on business needs and/or eligibility.

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Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development