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Associate Scientist, Downstream Process Development

Employer
GSK
Location
Collegeville, Pennsylvania
Salary
Competitive
Closing date
Oct 13, 2022

View more

Discipline
Physical Sciences, Chemistry, Other, Manufacturing/QA/QC
Job Type
Staff Scientist
Organization Type
Pharma
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Are you looking for a challenging opportunity that allows you to leverage your technical expertise to accelerate delivery in biopharmaceuticals? If so, this Associate Scientist, Biopharm Downstream Process Development role could be an exciting opportunity to explore.

Biopharm Process Development is a highly experienced Chemistry, Manufacturing and Controls (CMC) organization accountable for delivering robust, cost effective and competitive products and manufacturing processes spanning the full life-cycle of asset development from Discovery through commercialization. These activities are delivered through state-of-the-art internal facilities as well as strategic external partners. Collectively, the team is accountable for CMC activities encompassing cell line development, cell culture/ microbial fermentation, purification development, and drug product/ device development. We also pioneer innovative technologies to improve robustness, reduce cost of goods, and improve the patient experience.

Within Biopharm Drug Substance Process Development, the Downstream Process Development department is responsible for the development of purification processes for the manufacture of GSK's Biopharm assets. The Department is also responsible for the scale-up and tech transfer of the processes to manufacturing facilities all over the world. Our aim is to integrate innovative process platforms, automation and advanced data analytics into the downstream process development workflow.In our mission, we follow the science and are committed to the design, development, and transfer of the most robust, well-understood, and well-characterized downstream manufacturing processes and platforms that will ensure quality and reliable supply of medicines for the patient.

As an Associate Scientist in Downstream Process Development, you will be a member of a highly skilled team of scientists and engineers responsible for the evaluation and optimization of purification processes. You will be involved in all aspects of the development of purification processes including initial process screening, optimization and characterization, scale-up and tech transfer to clinical manufacturing and/or commercial manufacturing partners for therapeutic proteins including monoclonal antibodies, and antibody-drug conjugates. Your primary focus will be on the bench-scale laboratory development of purification unit operations such as column chromatography (affinity, ion exchange, HIC, mixed mode, etc.), ultrafiltration, depth filtration and continuous centrifugation. Although predominantly lab-based, the role also involves verbal and written communication and requires good organization. Both individual and team working are required and therefore the role will suit a scientist with good interpersonal skills, self-motivation and an open mindset.

This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following:
  • Bench-scale laboratory development of purification unit operations such as column chromatography (affinity, ion exchange, HIC, etc.), ultrafiltration, depth filtration and centrifugation
  • Initial process screening; optimization and characterization; virus clearance validation
  • Scale-up and tech transfer to clinical manufacturing and/or commercial manufacturing partners
  • Execution and documentation of scientific experiments in a timely manner and with high quality


Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:
  • Master's degree (Chemical Engineering, Biochemistry, Chemistry or Biology) or Bachelor's degree plus relevant academic or industry laboratory experience
  • Experience with protein chemistry and purification techniques
  • Experience with routine laboratory techniques or plant equipment/operations
  • Demonstrated ability to learn new techniques independently


Preferred Qualifications:

If you have the following characteristics, it would be a plus:
  • Purification process development experience
  • Basic knowledge of GxP policies and procedures; basic knowledge of regulatory requirements of the pharmaceutical and/or biotechnology industry
  • Excellent verbal and written communication skills
  • Strong organizational skills


Why GSK?

Uniting science, technology and talent to get ahead of disease together

GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years.

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued and included. Where they can keep growing and look after their wellbeing.So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

*LI-GSK

#CMCDevelopmentGSK

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve.

GSK has made the decision to require all US employees to be fully vaccinated against COVID-19, where allowed by state or local law and where vaccine supply is readily available. The only exceptions to this requirement are employees who are approved for an accommodation for religious, medical or disability-related reasons.

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