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Investigator, Novel Human Genetics

Employer
GSK
Location
Collegeville, Pennsylvania; Collegeville, Pennsylvania
Salary
Competitive
Closing date
Oct 11, 2022

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GlaxoSmithKline is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.

The Novel Human Genetics Research Unit (NHG RU) at GSK comprises a multidisciplinary biology team that utilizes deep scientific knowledge and technical capabilities to identify and validate novel therapeutic targets with human genetic association to diseases and undertake drug discovery efforts from early stage discovery through to phase 1 clinical trials. The NHG RU conducts drug discovery across a range of therapeutic areas including neuroscience, cardiovascular, renal, and metabolic diseases.

We are seeking to hire a highly motivated biologist to fill a Scientific Investigator position in the Novel Human Genetics Research Unit in R&D. The successful candidate will be part of a multidisciplinary team to establish and characterize cellular models derived from induced pluripotent stem cells (iPSCs), and to perform genetic perturbations (KD, KO, KI, overexpression) in iPSCs or iPSC-derived cells for drug discovery applications. The scientist will have the opportunity to work on targets and pathways relevant to a variety of human diseases and therapeutic areas.

Job functions:
  • Function as a technical expert in iPSC culturing, establishing and optimizing iPSC differentiation into cell types.
  • Perform QC assays for characterization of iPSC-derived cellular models, and prepare cells for various assays (i.e., RNA-seq).
  • Conduct gene editing and optimize conditions to achieve high efficiency genetic perturbations (KD, KO, KI, overexpression) in iPSCs or iPSC-derived cells
  • Conceive, design and conduct cellular experiments (including RT-qPCR, ELISA, high content imaging, etc) addressing specific biological questions, analyze and report experimental data using a variety of laboratory instruments and computer softwares.
  • Collaborate with internal colleagues and CROs to establish/transfer proceduresfor iPSC culturing and differentiation.
  • Commit to continual improvement by reading and applying the latest scientific literature, methodologies and technologies
  • Comply with all standards and practices of data integrity, ethics, and safety
  • Model GSK's values of patient-focus, respect, transparency, and integrity
  • Communicate processes and study results with project team and line leaders


Why You?

Basic qualifications:
  • PhD in biological sciences
  • Five or more years of relevant experience in molecular biology and/or cell biology.
  • Three or more years of experience in the following areas:
    • iPSC culturing and differentiation
    • Genetic manipulation techniques including siRNA and gene overexpression
    • Cell-based assays (e.g. immune-sandwich, ELISA, reporter gene assay, etc.)
    • Executing experiments independently and work collaboratively with colleagues
    • Analyzing, summarizing, interpreting, presenting experimental data, and maintaining accurate/legible records.


Preferred qualifications (one or more of the following):
  • PhD in biological sciences with three or more years of post PhD. experience in molecular biology and cell biology
  • Experience using viral delivery vectors
  • Experience with CRISPR genome editing technologies
  • Experience with FACS cell analysis
  • Experience with high content imaging and data analysis
  • Experience with iPSC differentiation into hepatocytes or a neural cell type
  • Strong documentation, communication, and teamworking skills


Why GSK?

At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader inConsumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggestchanges we've made to our business in over 20 years.We're on track to separate and create two new companies in 2022:New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and geneticsscience; and a new world-leading consumer healthcare company of loved and trusted brands.​

With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of diseasetogether - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; andas a new GSK where outstanding people thrive.​

Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culturethat isambitious for patients- so we deliver what matters better and faster;accountable for impact- with clear ownership ofgoals and support to succeed; andwhere we do the right thing. So, if you're ready to improve the lives of billions, join us at thisexciting moment in our journey. Join our challenge to get Ahead Together.​

*LI-GSK

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve.

GSK has made the decision to require all US employees to be fully vaccinated against COVID-19, where allowed by state or local law and where vaccine supply is readily available. The only exceptions to this requirement are employees who are approved for an accommodation for religious, medical or disability-related reasons.

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