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Investigator, Novel Human Genetics

Collegeville, Pennsylvania; Collegeville, Pennsylvania
Closing date
Oct 11, 2022

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GlaxoSmithKline is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.

The Novel Human Genetics Research Unit (NHG RU) at GSK comprises a multidisciplinary biology team that utilizes deep scientific knowledge and technical capabilities to identify and validate novel therapeutic targets with human genetic association to diseases and undertake drug discovery efforts from early stage discovery through to phase 1 clinical trials. The NHG RU conducts drug discovery across a range of therapeutic areas including neuroscience, cardiovascular, renal, and metabolic diseases.

We are seeking to hire a highly motivated biologist to fill a Scientific Investigator position in the Novel Human Genetics Research Unit in R&D. The successful candidate will be part of a multidisciplinary team to establish and characterize cellular models derived from induced pluripotent stem cells (iPSCs), and to perform genetic perturbations (KD, KO, KI, overexpression) in iPSCs or iPSC-derived cells for drug discovery applications. The scientist will have the opportunity to work on targets and pathways relevant to a variety of human diseases and therapeutic areas.

Job functions:
  • Function as a technical expert in iPSC culturing, establishing and optimizing iPSC differentiation into cell types.
  • Perform QC assays for characterization of iPSC-derived cellular models, and prepare cells for various assays (i.e., RNA-seq).
  • Conduct gene editing and optimize conditions to achieve high efficiency genetic perturbations (KD, KO, KI, overexpression) in iPSCs or iPSC-derived cells
  • Conceive, design and conduct cellular experiments (including RT-qPCR, ELISA, high content imaging, etc) addressing specific biological questions, analyze and report experimental data using a variety of laboratory instruments and computer softwares.
  • Collaborate with internal colleagues and CROs to establish/transfer proceduresfor iPSC culturing and differentiation.
  • Commit to continual improvement by reading and applying the latest scientific literature, methodologies and technologies
  • Comply with all standards and practices of data integrity, ethics, and safety
  • Model GSK's values of patient-focus, respect, transparency, and integrity
  • Communicate processes and study results with project team and line leaders

Why You?

Basic qualifications:
  • PhD in biological sciences
  • Five or more years of relevant experience in molecular biology and/or cell biology.
  • Three or more years of experience in the following areas:
    • iPSC culturing and differentiation
    • Genetic manipulation techniques including siRNA and gene overexpression
    • Cell-based assays (e.g. immune-sandwich, ELISA, reporter gene assay, etc.)
    • Executing experiments independently and work collaboratively with colleagues
    • Analyzing, summarizing, interpreting, presenting experimental data, and maintaining accurate/legible records.

Preferred qualifications (one or more of the following):
  • PhD in biological sciences with three or more years of post PhD. experience in molecular biology and cell biology
  • Experience using viral delivery vectors
  • Experience with CRISPR genome editing technologies
  • Experience with FACS cell analysis
  • Experience with high content imaging and data analysis
  • Experience with iPSC differentiation into hepatocytes or a neural cell type
  • Strong documentation, communication, and teamworking skills

Why GSK?

At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader inConsumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggestchanges we've made to our business in over 20 years.We're on track to separate and create two new companies in 2022:New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and geneticsscience; and a new world-leading consumer healthcare company of loved and trusted brands.​

With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of diseasetogether - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; andas a new GSK where outstanding people thrive.​

Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culturethat isambitious for patients- so we deliver what matters better and faster;accountable for impact- with clear ownership ofgoals and support to succeed; andwhere we do the right thing. So, if you're ready to improve the lives of billions, join us at thisexciting moment in our journey. Join our challenge to get Ahead Together.​


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