GlaxoSmithKline is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.We have an exciting new position available within the Bioimaging team at GSK, based at our world-class R&D site in Collegeville, PA. The role will focus on development of In-vivo Bioimaging technologies including Magnetic Resonance Imaging/Spectroscopy (MRI/S) to advance our project decision making based on drug distribution and functional pharmacology mechanistic endpoints.
The successful candidate will work in a state-of-the-art pre-clinical Bioimaging facility located at the Upper Providence campus in Collegeville, PA. The facility houses: Bruker 4.7T/40 cm horizontal and 9.4T/8.9 cm vertical MRI systems; Mediso MultiScan LFER150 PET/CT; Siemens Inveon PET/SPECT/CT; a radiochemistry lab (synthesizing and dispensing all in one Capintec hot cell, Sofie Biosciences ELIXYS Platform, HPLC, TLC, Cell incubator), GE & VisualSonics Ultrasound; IVIS and FMT Optical imaging systems; Laser Doppler imaging equipment.We welcome applications from highly motivated individuals interested in delivering imaging biomarkers to support drug discovery and vaccines development efforts. The successful candidate will join a highly collaborative and motivated team of scientists focused on providing innovative solutions to help deliver safe and efficacious new medicines to patients.
Bioimaging at GSKThe Bioimaging department brings together key areas of in-vivo and ex-vivo imaging combined with histology to understand both disease state and intervention, combining data on drug distribution with the effect that distribution has on intact biological systems. At GSK we believe that the fewer barriers there are in delivering the science, the better our delivery of new medicines to patients. As part of the wider In Vitro/In Vivo Translation platform we encourage enterprise collaboration as well as external partnership with the wider scientific community to achieve our full potential.Key Responsibilities:
- Perform in-vivo Bioimaging studies (study design, protocol, data acquisition, and image analysis) to support the needs of Discovery Research and business partners ranging from drug design through safety evaluation to product/device development.
- Develop and apply state of the art MRI and MRS techniques to support drug discovery efforts within the organization.
- Provide imaging guidance/solutions and collaborate closely with the Bioimaging department.
- Responsible for study support and data generation/management and communication to project/program teams.
- Through collaboration with imaging and non-imaging colleagues, integrate in-vivo Bioimaging data with other methodologies as part of a multi-modal approach to drive critical project decisions.
- Responsible for implementing and maintaining instrument QC and service contracts with imaging vendors.
- Responsible for animal care and use protocol writing and oversight of the animal imaging protocols.
- Assure high standards for animal care and compliance with all federal, state, and local regulations.
- Ph.D. in Physics, Biophysics, or similar and a minimum of 1 year of post-doctoral and/or industrial experience working with non-invasive imaging technologies is required.
- Knowledge of visualization, statistics, and bioinformatic strategies.
- 1 or more years experience with troubleshooting and maintaining complex instrumentation.
- 1 or more years of established track record of continued scientific contributions through presentations and publications.
- Hands-on experience with Bruker MRI/S systems.
- Experience in performing In-vivo MRI/S studies in small and large animals and have training in integrative physiology and/or pharmacology.
- Experience designing and implementing MRI/S sequences for assessing disease modification, biomarker development, and clinical translation.
- Evidence of effective, collaborative interpersonal, organizational and communication skills, both oral and written, for working in a multi-disciplinary scientific team environment.
At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader in Consumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggest changes we've made to our business in over 20 years.We're on track to separate and create two new companies in 2022:
New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and genetics science; and a new world-leading consumer healthcare company of loved and trusted brands.
With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of disease together - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; and as a new GSK where outstanding people thrive.
Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culture that isambitious for patients
- so we deliver what matters better and faster;accountable for impact
- with clear ownership of goals and support to succeed; andwhere we do the right thing
. So, if you're ready to improve the lives of billions, join us at this exciting moment in our journey. Join our challenge to get Ahead Together.
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