Biotransformation scientist, US
- Employer
- GSK
- Location
- Collegeville, Pennsylvania
- Salary
- Competitive
- Closing date
- Oct 7, 2022
View more
- Discipline
- Physical Sciences, Chemistry
- Job Type
- Staff Scientist
- Organization Type
- All Industry, Pharma
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Are you a driven and motivated individual who has experience in metabolite identification and mass spectrometry ? Do you have strong scientific/technical knowledge to help support relevant processes at the site (e.g., how they impact the quality and efficacy of the final product)? If so, this could be an exciting opportunity for you.
As a Biotransformation Scientist, you will be responsible for delivering high-quality metabolism data for molecules across the GSK portfolio, allowing key decisions to be made, with impact on drug design, human safety and drug submission.
The Biotransformation Team (US) is part of the Global Disposition and Biotransformation Department within DMPK and is responsible for all metabolite identification activities that support a drug candidate from early discovery to clinical development, working with DMPK Project Representatives, Medicinal Chemists, Toxicologists and Clinical colleagues, through the coordinated use of analytical methods, including LC, MS, and NMR. The group uses state-of-the-art equipment in a modern laboratory and collaborates closely with other biotransformation scientists around the world in GSK. The successful candidate will have a strong background in biotransformation science and metabolite identification, with experience in designing, executing, and interpreting metabolism studies to aid Project Teams.
This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following…
Why you?
Basic Qualifications:
We are looking for professionals with these required skills to achieve our goals:
Preferred Qualifications:
If you have the following characteristics, it would be a plus:
Why GSK?
At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader inConsumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggestchanges we've made to our business in over 20 years.We're on track to separate and create two new companies in 2022:New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and geneticsscience; and a new world-leading consumer healthcare company of loved and trusted brands.
With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of diseasetogether - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; andas a new GSK where outstanding people thrive.
Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culturethat isambitious for patients- so we deliver what matters better and faster;accountable for impact- with clear ownership ofgoals and support to succeed; andwhere we do the right thing. So, if you're ready to improve the lives of billions, join us at thisexciting moment in our journey. Join our challenge to get Ahead Together.
Why GSK?
At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader inConsumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggestchanges we've made to our business in over 20 years.We're on track to separate and create two new companies in 2022:New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and geneticsscience; and a new world-leading consumer healthcare company of loved and trusted brands.
With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of diseasetogether - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; andas a new GSK where outstanding people thrive.
Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culturethat isambitious for patients- so we deliver what matters better and faster;accountable for impact- with clear ownership ofgoals and support to succeed; andwhere we do the right thing. So, if you're ready to improve the lives of billions, join us at thisexciting moment in our journey. Join our challenge to get Ahead Together.
Why you?
Basic Qualifications:
We are looking for professionals with these required skills to achieve our goals:
Preferred Qualifications:
If you have the following characteristics, it would be a plus:
Why GSK?
At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader inConsumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggestchanges we've made to our business in over 20 years.We're on track to separate and create two new companies in 2022:New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and geneticsscience; and a new world-leading consumer healthcare company of loved and trusted brands.
With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of diseasetogether - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; andas a new GSK where outstanding people thrive.
Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culturethat isambitious for patients- so we deliver what matters better and faster;accountable for impact- with clear ownership ofgoals and support to succeed; andwhere we do the right thing. So, if you're ready to improve the lives of billions, join us at thisexciting moment in our journey. Join our challenge to get Ahead Together.
#LI-GSK
If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).
GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.
At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve.
GSK has made the decision to require all US employees to be fully vaccinated against COVID-19, where allowed by state or local law and where vaccine supply is readily available. The only exceptions to this requirement are employees who are approved for an accommodation for religious, medical or disability-related reasons.
Important notice to Employment businesses/ Agencies
GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.
Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.
As a Biotransformation Scientist, you will be responsible for delivering high-quality metabolism data for molecules across the GSK portfolio, allowing key decisions to be made, with impact on drug design, human safety and drug submission.
The Biotransformation Team (US) is part of the Global Disposition and Biotransformation Department within DMPK and is responsible for all metabolite identification activities that support a drug candidate from early discovery to clinical development, working with DMPK Project Representatives, Medicinal Chemists, Toxicologists and Clinical colleagues, through the coordinated use of analytical methods, including LC, MS, and NMR. The group uses state-of-the-art equipment in a modern laboratory and collaborates closely with other biotransformation scientists around the world in GSK. The successful candidate will have a strong background in biotransformation science and metabolite identification, with experience in designing, executing, and interpreting metabolism studies to aid Project Teams.
This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following…
- Design and deliver metabolism studies in line with Discovery and Development DMPK key deliverables (acting as Study Director or Study Monitor)
- Provide mass spectrometry, together with, metabolite identification and prediction expertise to the DMPK organization
- Process results from assays using appropriate software and evaluate analytical data leading to authorship/review of high-quality reports, publications and regulatory dossiers
- Understand, interpret, and communicate biotransformation data to Project Representatives and key stakeholders
- Be able to troubleshoot, problem solve and define best practice for biotransformation studies
- Drive innovation by investigating and implementing new analytical technologies and procedures
- Contribute to the scientific strategy to enhance the value of biotransformation science to support a diversified GSK portfolio
- Create internal and external networks to drive science within their discipline
- Initiate new research directions and novel strategies to achieve project or department goals in biotransformation and analytical science (e.g., novel assays or experimental approaches, understanding the impact of drug metabolism on human safety and drug design). May identify new scientific opportunities for primary discipline
- Matrix as a DMPK subject matter expert with Project Representatives around the planning and timing of biotransformation studies and the impact on drug development
- Collaborate with others as required to ensure optimal delivery of biotransformation studies e.g., Clinical organization, Medicinal Chemistry to support the progression of projects
- Ensure data integrity and data accessibility through the GSK R&D data domains
- Ensure compliance with GSK Values and Policies
Why you?
Basic Qualifications:
We are looking for professionals with these required skills to achieve our goals:
- BS + 5 years' experience in relevant discipline
- MS + 3 years' experience in relevant discipline
- PhD in relevant discipline
- Two or more years of experience in metabolite characterization and quantification using mass spectrometry
- Two or more years of experience in the development of bespoke LC-MS methodologies for structure elucidation using state-of-the-art high-resolution instrumentation
- Two or more years of experience in generating high quality data and reports
- Two or more years of experience in vitro and in vivo approaches to understand biotransformation issues
- One or more years of experience in all aspects of the biotransformation discipline and an ability to integrate this knowledge into drug discovery and development programs
Preferred Qualifications:
If you have the following characteristics, it would be a plus:
- HPLC and chromotography skills
- Knowledge of spectroscopic techniques other than mass spectrometry, for example, NMR would be an advantage
- Experience in Drug Metabolism and Pharmacokinetic project representation
- High level of problem-solving capability by identifying and troubleshooting unexpected results or findings
- Strong communication and interpersonal skills
- Experience working in a matrix across departmental lines
Why GSK?
At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader inConsumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggestchanges we've made to our business in over 20 years.We're on track to separate and create two new companies in 2022:New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and geneticsscience; and a new world-leading consumer healthcare company of loved and trusted brands.
With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of diseasetogether - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; andas a new GSK where outstanding people thrive.
Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culturethat isambitious for patients- so we deliver what matters better and faster;accountable for impact- with clear ownership ofgoals and support to succeed; andwhere we do the right thing. So, if you're ready to improve the lives of billions, join us at thisexciting moment in our journey. Join our challenge to get Ahead Together.
Why GSK?
At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader inConsumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggestchanges we've made to our business in over 20 years.We're on track to separate and create two new companies in 2022:New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and geneticsscience; and a new world-leading consumer healthcare company of loved and trusted brands.
With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of diseasetogether - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; andas a new GSK where outstanding people thrive.
Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culturethat isambitious for patients- so we deliver what matters better and faster;accountable for impact- with clear ownership ofgoals and support to succeed; andwhere we do the right thing. So, if you're ready to improve the lives of billions, join us at thisexciting moment in our journey. Join our challenge to get Ahead Together.
Why you?
Basic Qualifications:
We are looking for professionals with these required skills to achieve our goals:
- BS + 5 years' experience in relevant discipline
- MS + 3 years' experience in relevant discipline
- PhD in relevant discipline
- Two or more years of experience in metabolite characterization and quantification using mass spectrometry
- Two or more years of experience in the development of bespoke LC-MS methodologies for structure elucidation using state-of-the-art high-resolution instrumentation
- Two or more years of experience in generating high quality data and reports
- Two ro more years of experience in vitro and in vivo approaches to understand biotransformation issues
- One or more years of experience in all aspects of the biotransformation discipline and an ability to integrate this knowledge into drug discovery and development programs
Preferred Qualifications:
If you have the following characteristics, it would be a plus:
- HPLC and chromotography skills
- Knowledge of spectroscopic techniques other than mass spectrometry, for example, NMR would be an advantage
- Experience in Drug Metabolism and Pharmacokinetic project representation
- High level of problem-solving capability by identifying and troubleshooting unexpected results or findings
- Strong communication and interpersonal skills
- Experience working in a matrix across departmental lines
Why GSK?
At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader inConsumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggestchanges we've made to our business in over 20 years.We're on track to separate and create two new companies in 2022:New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and geneticsscience; and a new world-leading consumer healthcare company of loved and trusted brands.
With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of diseasetogether - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; andas a new GSK where outstanding people thrive.
Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culturethat isambitious for patients- so we deliver what matters better and faster;accountable for impact- with clear ownership ofgoals and support to succeed; andwhere we do the right thing. So, if you're ready to improve the lives of billions, join us at thisexciting moment in our journey. Join our challenge to get Ahead Together.
#LI-GSK
If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).
GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.
At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve.
GSK has made the decision to require all US employees to be fully vaccinated against COVID-19, where allowed by state or local law and where vaccine supply is readily available. The only exceptions to this requirement are employees who are approved for an accommodation for religious, medical or disability-related reasons.
Important notice to Employment businesses/ Agencies
GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.
Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.
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