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Scientist, In Vitro Pharmacology (non-PhD)

Cambridge, Massachusetts
Closing date
Oct 11, 2022

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Life Sciences, Pharmacology, Physical Sciences, Chemistry
Position Type
Full Time
Job Type
Staff Scientist
Organization Type
All Industry, Pharma
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Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

The Internal Medicine Research Unit (IMRU) is seeking a highly motivated laboratory scientist to be a member of the In Vitro Pharmacology/Assay Development group. This Scientist will be an integral member of a team which broadly supports the IMRU portfolio across all the disease areas of interest. The individual will apply a scientific background in in vitro pharmacology to develop primary assays for carrying out SAR (structure-activity relationships) and design/execute experiments for understanding the mechanism of action of compounds throughout different stages of the project. In this position, the successful candidate will work within a large matrix environment, across a portfolio of programs, collaborating with multiple groups including discovery biology and several partner lines including Medicinal Chemistry and the Primary Pharmacology Group.

How You Will Achieve It

  • Develop robust biochemical and cell-based compound screening assays across a broad array of target classes
  • Perform low to moderate throughout screening for small molecule and antibody modalities
  • Maintain immortalized, primary, or iPS cell cultures for assay development and low volume screening efforts as needed
  • Operate a broad array of liquid-handling and plate-based pharmacology equipment to ensure efficient automated workflows for newly developed assays
  • Collaborate with Primary Pharmacology Group and external vendors to ensure alignment around assay quality criteria and efficient assay transfer as needed
  • Prepare and present experimental results to project teams
  • Maintain high quality experimental records within electronic laboratory notebook


  • BA/BS degree with 6+ years OR MA/MS degree with 4+ years experience in Biology, Pharmacology, Biochemistry or a related field
  • At least 2 years experience in an industrial setting.
  • Broad understanding of Biology, preferably with an emphasis in Metabolism
  • Scientific understanding of the major target classes (GPCRs, Enzymes, Transporters, Ion channels, etc.)
  • Experience with assay development methodologies
  • Experience in low to moderate throughput compound screening
  • Experience with cell culture (primary and immortalized)
  • Ability to conduct data analysis using Microsoft Excel, GraphPad PRISM, or equivalent software
  • Ability to complete experiments and present results in individual and group settings
  • Ability to work on multiple programs simultaneously and be an integral member of cross-functional project teams
  • Proven verbal and written communication skills, and the ability to work in a collaborative team environment

  • Experience with automation of liquid handling and screening workflows



Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development
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