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Scientist, Cell Biology and Translational Research

Employer
Pfizer
Location
Boulder, Colorado
Salary
Competitive
Closing date
Oct 11, 2022
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Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

As a Scientist, you will be at the center of our operations and you'll find that everything we do, every day, is in line with an unwavering commitment to quality. You will be part of a team that is addressing the critical task of rejuvenating our pipeline with innovative, differentiated First-In-Class/ Only-In-Class programs in the years to come. This will be addressed by generation of strong data packages from target hypotheses derived from academic outreach and initiatives. You will be an essential member of this team and creatively design and execute key experiments to address the basic and translational biology of novel drug targets, their molecular pathways, and their connection to human disease. You will support projects in one or more therapeutic areas of interest to Pfizer including Immunology, Oncology, Immuno-Oncology, Neurodegenerative Disease, etc.

With your deep knowledge in the discipline, you will be an active team member who influences at the project team level. You will be using your scientific judgment to adapt standard methods and techniques by applying prior work experience and consulting others. Your ability to plan will help in preparing short-term work activities on projects. Your creativity in developing novel processes and new ideas will be used frequently. You will undertake mentoring activities to guide your team members.

It is your innovative scientific temperament that will help in making Pfizer ready to achieve new milestones and help patients across the globe.

How You Will Achieve It

  • Independent development of cellular screening assays and execution of regular compound screening in support of drug discovery projects.
  • Processing of experimental data and presentation to cross-functional team members, recognizing and highlighting implications for broader discovery efforts.
  • Application of a variety of cell and molecular biology techniques, including gene targetingand small molecule inhibition approaches, for determination of compound mechanism of action.
  • Experimental evaluation of target dependency, off-target liabilities, phenotypic responses, resistance mechanisms, and beneficial drug combinations.
  • Comply with all safety training and good laboratory practices.


Qualifications

Must-Have
  • BS in a relevant discipline with 6+years or MS with 4+ years of experience in a biopharmaceutical industry setting.
  • Experience in experimental design and hands-on implementation of standard molecular and cellular biology techniques.
  • Skilled in a wide range of state-of-the-art molecular and cellular biology techniques.
  • Extensive hands-on experience developing and executing cell-based compound screening assays in a variety of formats (ELISA/MSD, Licor In-cell western, flow cytometry, transcriptional reporters, etc.).
  • Experience with automated liquid handling systems for execution of medium to high-throughput screening experiments.
  • Proficiency with standard analytical software (e.g., ExcelFit, GraphPad Prism, Spotfire, Vector NTI, Flowjo).
  • Demonstrated success working with cross-functional teams.
  • Strong communication, documentation, and organizational skills.
  • Ability to listen effectively and stimulate response and discussion in a team setting.


Nice-to-Have
  • Experience in new target discovery and validation.
  • CRISPR-cas9 gene editing for cell line engineering
  • Familiarity with interpretation of complex data sets such as those resulting from NGS and proteomics studies.


PHYSICAL/MENTAL REQUIREMENTS
  • Standing, sitting, bending, lifting, walking, and repetitive pipetting in a laboratory setting.
  • Ability to perform basic mathematical calculations (e.g., converting concentration from mass/volume to molarity, determining dilution factors, calculating assay statistics).
  • Ability to read, understand, and perform written protocols.
  • Ability to perform moderately complex data analysis.


NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

  • Ability to work outside of normal business hours as necessary to complete essential tasks.
  • Adherence to safe laboratory practices and procedures.


Other Job Details:
  • Relocation support available


#LI-PFE

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

#LI-PFE
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