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Senior Scientist, Molecular Pharmaceutics, Drug Product Design

La Jolla, California
Closing date
Oct 10, 2022

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Position Summary:

The key purpose of this position is to influence and advance the early candidate substrate from a physical, chemical, drug delivery, and bioperformance perspective through close collaboration with partners on the Discovery project teams and in Pharmaceutical Science. You will need to act as a resident pharmaceutical science subject matter expert to inform, educate and influence Discovery teams in finding New Chemical Entities (NCEs) with desirable drug delivery and performance properties. This will include assessment of in silico, in vitro and in vivo data as well as design of stage appropriate formulations for preclinical studies. An awareness of later stage development needs as well as an understanding of the disease state and biology will help to enable the definition of the required design elements.

  • Closely collaborate with Drug Discovery partners to evaluate molecular attributes relevant to drug delivery and influence team strategies
  • Design and develop fit for purpose preclinical formulations (traditional and enabling) to enable robust candidate selection and progression
  • Assess and clearly communicate drug delivery and performance risks (using in silico, in vitro and in vivo data as well as sound scientific principles)
  • Assess solid form aspects of molecular substrate and communicate risks
  • Maintain an awareness of and contribute to scientific literature; actively apply new concepts as appropriate
  • Conduct novel research and present significant findings via internal and external presentations or publications

Organizational Relationships:

This position will interface with multidisciplinary teams and work closely with colleagues in Medicinal Chemistry, Biology, Drug Safety and Pharmacokinetics Dynamics & Metabolism. Strong relationships with Clinical, Analytical, Materials Science, Biopharmaceutics, and late stage Formulation colleagues are also expected.

Education and Experience:

M.S. with >5 years of relevant experience or PhD in Pharmaceutics, Chemistry, Medicinal Chemistry, Physical Chemistry, or Biophysics

Technical Skills Experience:

Skills in the following areas are required for this position:
  • Computational chemistry tools to predict physical properties and the translation of molecular properties to predict bioperformance
  • Modeling of oral absorption phenomena and the interpretation of in vitro/in vivo ADME data
  • Design of typical formulation approaches and routes of administration across multiple species
  • Strong organizational, interpersonal, written, and verbal communication skills
  • Strong scientific leadership and direction of new technology initiatives
  • Application of fundamental principles to solve complex problems


Candidates must have the ability to perform laboratory work.
Relocation support available

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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