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Principal Scientist, Enzymology

Boulder, Colorado
Closing date
Oct 10, 2022

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Physical Sciences, Chemistry
Position Type
Full Time
Job Type
Staff Scientist
Organization Type
All Industry, Pharma
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We are seeking a highly motivated, exceptional biochemist to support early-stage drug discovery efforts at our Pfizer, Boulder Research & Development site in Boulder, CO. This individual will be responsible for developing high-throughput screens, biochemical potency assays, and mode-of-action studies in a collaborative team environment. The candidate will work closely with structural biologists, protein chemists, computational, and medicinal chemists and will take a functional leadership role on their project team(s) in our fast-paced drug discovery environment aimed at creating "breakthroughs that change patients' lives."

  • Plans, performs, and analyzes biochemical experiments in an independent and timely manner
  • Serves as the enzymology lead on project teams by developing assays to evaluate compound potency and communicates the results to project teams
  • Engages with the literature to drive an understanding of the project's target, and designs experiments to interrogate the mode of action of ligands
  • Serves as a scientific resource and mentor for junior colleagues
  • Evaluates new platforms and methodologies for internalization
  • Interacts with research staff in other departments to accomplish project goals

  • Ph.D. in Biochemistry or related field with 5+ years of relevant post-graduate experience or M.S. with 10+ years of relevant post-graduate experience
  • Experience in conducting and analyzing in vitro biochemical assays to elucidate the mode of action of small molecule ligands
  • Knowledge and practical experience with enzyme kinetics (e.g., history of using methods for determining mode of inhibition, kinact/Ki, allosteric behavior, etc)
  • Strong problem-solving skills as evidenced by successful examples or peer-reviewed publications that raise, investigate, and elucidate scientific questions
  • Capable of operating independently with regard to technical problems and procedures
  • Excellent oral and written communication, including to audiences without biochemistry expertise
  • Track record of successful scientific mentorship of junior scientists
  • Ability to perform complex data analysis and proficient in the use of computer software to fit and interpret analytical data such as GraphPad, XLFit & Spotfire

  • Experience with laboratory automation and HTS workflows
  • Experience conducting assays in microtiter plates
  • Familiarity with protein expression, structural biology, and biophysical methods


Lifting, sitting, standing, walking, bending, and manual dexterity/visual acuity to operate in microtiter plates.


Able to adhere to safe work practices and perform lab work with appropriate personal protective equipment such as but not limited to safety goggles, gloves, lab coat, and closed toe shoes.
\nRelocation support available\n
Work Location Assignment: On Premise

For roles based in Colorado: The annual base salary for this position ranges from $93,200.00 to $155,400.00. In addition, this position offers an annual bonus with a target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. Benefits offered include a retirement savings plan, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

Relocation assistance may be available based on business needs and/or eligibility.

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development
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