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Senior Associate Scientist - Downstream Process Development, Bioprocess R&D

Andover, Massachusetts
Closing date
Oct 10, 2022

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The pu r pose of the Senior Associate Scien t ist position is to provide the planning and execution of experiments designed to aid in defining manufacturing processes for biopharmaceuticals. The successful candidate will have a working knowle dge of biochemistry, and related analytical chemistries , chromatography , centrifugation, precipitation, and filtration design principles . This position requires the design and execution of experiments using these technologies and the ability to evaluate and clearly reporting the results to laboratory colleagues and other affected functional areas.


The successful S enior Associate Scientist applicant will have experience in laboratory research, and a desire to continue in a laboratory-focused role. This position will join a larger team of scientists across multiple sites focused on developing and optimizing recovery and purification processes for recombinant proteins and biological macromolecules for early- and late-phase clinical trials. The Senior Associate Scientist will be responsible for working with fellow scientists to develop robust, efficient, scalable strategies for improving process performance. Responsibilities will include small-scale studies, and pilot plant and manufacturing downstream purification studies. Based on the analyses of these studies, this position will be expected to develop and test new hypotheses to improve the fundamental understanding of recovery and purification processes. This position will support process validation, quality by design, regulatory approaches, and quality systems. This position will be expected to prepare internally reviewed technical reports, make oral presentations to scientists and management, and publish externally. The Senior Associate Scientist will be responsible for executing operational efficiency improvements and planning and implementing improvements across Bioprocess R&D work processes. The successful candidate must be able to endorse change to business infrastructure to ensure pipeline, legacy and technology success.


This position requires highly motivated individuals with the ability to work closely with other members of the laboratory and the department in a matrix team environment. This position will collaborate with pilot plant and manufacturing staff on experimental studies, clinical manufacturing, and process validation, including work with external contract manufacturing organizations


Must Have

  • BS (2+ years experience ) or MS degree in a biological or engineering discipline (Biotechnology, Biochemistry, Chemical/Biochemical Engineering, or equivalent)
  • 0-2 years experience in recombinant protein/biomolecule purification process development, technology transfer and/or bioprocess manufacturing required.
  • Demonstrated ability to drive for results and generate innovative research programs independently

Nice to Have
  • Applicants should be bright, organized, self-motivated, and capable of working independently, and in a collaborative environment.
  • The successful candidate will possess strong oral and written communication skills.
  • Diverse work experience recovering recombinant proteins/biomolecules from mammalian and microbial/yeast cultures.
  • Experience transferring Biotherapeutic processes to pilot plants or manufacturing organizations, and knowledge of data acquisition and controls systems in these environments is desirable.


  • A good understanding of protein chemistry, protein analytics, and bioprocess technology, including the recent scientific literature, is required.
  • Strong analytical and computer skills are required.
  • Sound understanding of statistical experimental design and analysis is a benefit.
  • It would be advantageous for the successful candidate to have a strong working knowledge of the drug development process for progression of a biological candidate.


This position will require standing for long periods of time in a laboratory setting. Long periods of sitting at computer work station are required. Occasional lifting of equipment may be required. Occasional travel to vendor worksites may be required.

Work Location Assignment:On Premise


Relocation assistance may be available based on business needs and/or eligibility.


Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development
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