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Pharmacometrician (Director)

La Jolla, California, United States;Remote, New York, United States;Collegeville, Pennsylvania, United States;Cambridge, Massachusetts, United States;
Closing date
Oct 9, 2022

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Health Sciences, Medicine
Position Type
Full Time
Job Type
Organization Type
All Industry, Pharma
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Role Summary
Member of Global Pharmacometrics group within the Clinical Pharmacology Department, responsible for providing expert study/program design, data analytical and interpretation inputs to various Research, Development and Business Unit organizations. Of key importance will be the formation and maintenance of effective collaborations with among team members, including statistical, clinical and clinical pharmacology colleagues.

  • Hands on contribution to MIDD, complementary to Pfizer processes, including Enhanced Quantitative Drug Development (EQDD) and Enhanced Clinical Trial Design (ECTD). Responsible for the planning and execution of relevant quantitative analyses.
  • Contribute to the Pharmacometrics group remit in performing MIDD activities (e.g., exposure response analysis, disease progression modeling, quantitative knowledge management, clinical trial design, decision analysis, and EQDD strategy).
  • Organize and manage project deliverables utilizing the appropriate expertise and resources (internally within the company and/or externally within consultant groups and academic institutions).
  • Act as "player-coach", both conducting modeling and simulation and facilitating conduct of analyses with other quantitative global clinical pharmacology colleagues.
  • Prepare formal presentations and written reports to Pfizer standards.
  • Contribute to Pharmacometrics ability to act as a conduit for cross learnings within/across the clinical development organizations.
  • Provide effective partnership with other colleagues, proactively providing peer review, mentorship, consultancy, and technical input on quantitative issues.
  • Promote, educate, and mentor others in application of quantitative techniques and share experiences through appropriate local and global discussions.
  • Prepare and deliver training on quantitative tools and methodologies internally to Pharmacometricians and other global clinical pharmacology colleagues.
  • Contribute with project teams/partners to regulatory responses and submissions.
  • Stay abreast of literature, government guidelines, and internal guidance as relates to pharmacometrics and MIDD, including internal SOPs and regulations in order to be a team resource of pharmacometric knowledge in terms of analytical methodology, medical background, and clinical trial design.
  • Able to produce and present quality scientific papers at external meetings and for publication. With line management endorsement, manages and initiates external collaborations with world leading pharmacotmetric and quantitative clinical pharmacology experts to develop new methodologies.
  • Recruit, train, develop, mentor, motivate and retain highly skilled Pharmacometricians.
  • Work with quantitative colleagues across disciplines to ensure delivery and communication of best practices.
  • May represent group on company initiative sub-teams.
  • May participate in multidisciplinary teams in assessing potential in-licensing opportunities, as requested by line management.
  • May collaborate with, enable and influence external key opinion leaders and regulatory authorities in best practices for drug development science through publication, external presentation.
  • May develop best-in-class strategic alliances with industrial and academic centers of excellence for drug development and research.
  • May participate in and contribute to global computational sciences community of practice.
  • Contribute to business requirements/support of IT colleagues/contractors, systems and tools to ensure support services to systems and software tools and colleagues are best in class.

  • M.S. with 12+ years or Pharm.D and/or PhD degree with 9+ years of training and/or expertise in one or more areas related to pharmacostatistical modeling.
  • An interest and experience of pharmacostatistical methods of data analysis and study design are essential.
  • Candidates from alternative backgrounds (e.g. mathematics, engineering, system biology) will be considered if they can demonstrate relevant experience and expertise.

  • Strong science and quantitative analysis background, with good working knowledge of biology, chemistry, pharmacology, engineering and/or statistics.
  • Good computational skills.
  • Good knowledge of a range of MIDD software (R, NONMEM, STAN, etc.).
  • Good communication skills (written, oral presentation).
  • Balance multiple responsibilities, projects and teams simultaneously.
  • Adapt and be dynamic.
  • Identify and understand relevant scientific literature and apply knowledge gained from these sources desired.
  • Identify/develop and apply new quantitative methods as needed to solve problems in pharmaceutical research.
  • Interpret a range of model types and identify scientific, technical and methodology strengths and weaknesses.

Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
Work Location Assignment: Flexible

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

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