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Principal Scientist, Cheminformatics

Employer
Pfizer
Location
Cambridge, Massachusetts
Salary
Competitive
Closing date
Oct 9, 2022

View more

Discipline
Physical Sciences, Chemistry
Position Type
Full Time
Job Type
Staff Scientist
Organization Type
All Industry, Pharma
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ROLE SUMMARY

At Pfizer, the Medicine Design department focuses on small molecule drug discovery efforts in multiple disease areas. We are striving to apply cutting-edge computational methods on comprehensive datasets to elucidate the molecular mechanisms of disease and drive the development of novel therapeutics. Our location in Cambridge MA is at the center of biomedical innovation, facilitating collaborations with local universities and biotech companies.

The cheminformatics-focused Computational Pharmacology Group within Medicine Design is seeking an experienced and self-driven individual to design and implement cheminformatics techniques and workflows to help accelerate our drug discovery process. The successful candidate will play a key role in unlocking the underlying value of Pfizer's wealth of proprietary pharmacology and related research data. The ideal candidate will design, deploy and automate data workflows to mine, organize and integrate data from a variety of internal and external database sources. The candidate will also develop cheminformatics analytics methods and tools that support the decision-making process of drug designers on projects across all of Pfizer's therapeutic areas. The scientist will have opportunities to make impact directly on drug discovery projects through clear communication of actionable insights with data-driven analyses. With strong communication skills and adept at building productive partnerships, the successful candidate will thrive working in cross-functional teams with talented scientists across different disciplines. The ability to think innovatively, manage complex technical challenges, strong attention to detail, and a drive to problem solving will make this role a success.

ROLE RESPONSIBILITIES
  • Mine pharmacology and other related data from internal and external databases
  • Organize data into integrated database to enable efficient cheminformatics-based methods development
  • Design, develop and deploy reproducible computational data workflows and data analytics tools
  • Collaborate with design chemists and screening experts to impact hit identification efforts
  • Analyze large-scale and complex data sets for actionable insights to enable project teams with decision making
  • Generate predictive (statistical, AI/ML) models to support drug design
  • Establish scientific and technical expertise through familiarity with scientific literature and attending conferences


QUALIFICATIONS

Basic Qualifications
  • PhD/MS in cheminformatics, computational chemistry, chemistry, or equivalent
  • 2+ years (MS: 5+ years) of relevant research experience, preferably in the pharmaceutical/biotech industry
  • Proficient in programming (Python, R) and database mining (SQL)
  • Experience with modern data modeling and mining Python/R libraries and toolkits (OEChem, RDKit)
  • Experience with data analytics and workflow platforms (Pipeline Pilot, Knime)
  • Demonstrated ability to organize, analyze, and derive insights from pharmacology and related data
  • Outstanding teamwork and communication skills
  • Ability to work well in multidisciplinary teams in a matrixed drug discovery environment


Preferred Qualifications
  • Experience with database design and processing (SQL/NoSQL, RestAPI, XML, json)
  • Experience in large-scale data handling and developing data pipelines
  • Expertise in generating data analytics and visualizations (Spotfire)
  • Experience in developing code in a collaborative manner (Code review, Design discussions)
  • Experience with CI/CD and test-driven development (GitHub, Bitbucket, GitLab)


PHYSICAL/MENTAL REQUIREMENTS
  • Sitting, standing, lifting, bending, and walking. Ability to work on a computer (while standing or sitting). Ability to perform mathematical calculations and interpret data.



NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
  • Candidate will be asked to occasionally travel to the Pfizer site in Groton, CT to meet colleagues from other departments.


Additional Job Information:
  • Relocation Support Available
  • Eligible for employee referral bonus


#LI-PFE

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Relocation assistance may be available based on business needs and/or eligibility.

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Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development
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