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Senior Principal Scientist - Process Chemistry

Groton, Connecticut
Closing date
Oct 5, 2022
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We are seeking an experienced synthetic organic chemist to join the Process Chemistry group within Chemical Research and Development (CRD) in Groton. CRD, as part of Worldwide R&D in Pharmaceutical Sciences, is responsible for the development of process technology for the production of active pharmaceutical ingredients (API). CRD scientists engage in all facets of development from small scale synthesis in support of Discovery programs, to the development of the commercial synthetic route. CRD scientists partner with manufacturing specialists for API synthesis in kilo-lab and pilot plant facilities, as well as provide support for technology transfer to Pfizer manufacturing sites and third party facilities.

The successful candidate will have a high-level knowledge of process chemistry, and will design, enable and develop scalable processes to pharmaceutical drug candidates, applying innovative chemistries, new technologies and statistical experimental design approaches in a laboratory setting. The ability to lead or work on multi-disciplinary teams involving chemists, analysts, engineers, and technologists and to represent CRD on cross-functional teams is essential.


The successful candidate would propose and identify efficient and robust synthetic routes for the preparation of API's. This position requires laboratory experimentation, leadership on API project teams and close collaboration with scientists from Analytical R&D and other disciplines such as engineering to further develop synthetic routes into safe, efficient and robust processes.

Interpretation of analytical data to drive synthetic experimental plans and the ability to utilize tools such as electronic notebooks to document information are essential. The successful candidate would also be responsible for participating in the preparation of technical transfer documents for manufacture internally or at third parties.

The successful candidate would lead unit of work teams or API project teams. A strong working knowledge of current Good Manufacturing Processes (GMP) is desired. Compliance on safety and regulatory requirements is expected and documented through our internal training program.

The successful candidate would also represent CRD on cross disciplinary programs within Pharmaceutical Sciences and contribute to continuous improvement work in the department and advancement of the Process Chemistry discipline through technology, workflow or business impact.


PhD. in Organic Chemistry, with 7+ years of pharmaceutical R&D experience in Process Chemistry required.

State of the art knowledge of modern synthetic methodology, including aspects of asymmetric synthesis, green chemistry, catalysis and physical organic chemistry as it relates to reaction mechanism is expected. The ability to employ analytical tools, computational and statistical methodology, and automated laboratory technologies to enhance process development efficiency is desirable.

Excellent written and oral communication skills, the ability to effectively influence the work of others, and a general knowledge of drug development and the pharmaceutical industry are key.

Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

Please upload a resume/CV and research summary


Laboratory work requiring standing.

Working at a computer.

Ability to use sound scientific judgment and analyze data to advance programs.


Travel is required on occasion in support of external manufacture, technology transfer or to participate in scientific conferences.

Other Job Details:
  • Eligible for Relocation Package: YES
  • Eligible for Employee Referral Bonus: YES

Work Location Assignment:On Premise

On Premise colleagues work in a Pfizer site because it's needed to get their job done. They may have flexibility to work remotely from time to time, but they are primarily on-site.


Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development
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