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Postdoctoral Fellow: Systems-Wide Protein Turnover Analysis With Mass Spectrometry Based Proteomics

Andover, Massachusetts
Closing date
Oct 9, 2022

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Life Sciences, Proteomics
Position Type
Full Time
Job Type
Postdoc Fellowship
Organization Type
All Industry, Pharma
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An exciting postdoc position is available in the Biomedicine Design department at Pfizer, Andover for a highly motivated and driven PhD graduate with solid expertise in advanced mass spectrometry-based proteomics and associated bioinformatics tools. This role provides unique opportunities for development of novel and innovative mass spectrometry assays for large scale measurement of physiological protein turnover in human and preclinical species.

The successful applicant will develop and implement different sample preparation strategies from various tissue and biofluid matrices. Also, development of novel and intelligent targeted and non-targeted high resolution mass spectrometry methods and utilizing MS database search engine tools for protein identification and turnover measurement are in scope of the role. High impact publication in top tier journals is expected. Candidate will work with bioinformatics and translational modeling and simulation experts and has the opportunity to become familiar with translational sciences supporting drug development. This position requires solid technical expertise in high resolution LC-MS/MS, associated samples preparation and proteomics data analysis.

  • Responsible for the development of samples preparation techniques from various matrices and development of targeted and non-targeted high resolution mass spectrometry methods for proteome turnover analysis
  • Proactive engagement with the literature to use cutting edge science for novel and innovative methods to overcome challenges facing the project
  • As a strong collaborator seeking guides and communicates with colleagues and advisors for timely achievements of the goals and milestones
  • Use of bioinformatics and software tools for data analysis, interpretation and classification
  • Providing periodic progress reports and presenting at internal and external conferences or meetings and publishing at top tier journals

  • Ph.D. in chemistry, biochemistry or related disciplines is required
  • Expertise in development and implementation of assays based on protein mass spectrometry
  • Experience and knowledge in operation of modern high resolution ion trap/orbitrap and triple quadrupole mass spectrometers and associated control and data analysis software systems
  • Knowledge and application of complex sample preparation methodologies as applied to protein mass spectrometry workflows techniques including tissue preparation/bioanalysis, samples fractionation and immuno-analytical techniques
  • Good level of expertise in the relevant bioinformatics tools and software for mass spectrometry data analysis and interpretation


Lab based position requiring performing all typical laboratory related activities

Occasional travel to Cambridge (Kendal Square) is required, depending on project needs


Eligible for Relocation Assistance

Must have Work Authorization in the US


Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development
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