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Scientist, Quantitative Protein Mass Spectrometry

Andover, Massachusetts
Closing date
Oct 1, 2022

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Physical Sciences, Chemistry
Position Type
Full Time
Job Type
Staff Scientist
Organization Type
All Industry, Pharma
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Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best - in - class medicines to patients around the world.

What You Will Achieve

Are you a bioanalytical scientist interested in contributing to the field of quantitative protein mass spectrometry? Join us as a Scientist on the Biomeasures LCMS team at Pfizer located in Andover, MA. You will be contributing to all aspects of development, implementation, execution, and analysis of high sensitivity LCMS assays for protein target quantification across the Pfizer portfolio in multiple matrices (serum, plasma, tissues, extracellular vesicles, etc) using state-of-the-art enrichment and instrumental techniques. This is a great opportunity to broadly apply your growing expertise to emerging areas of bioanalysis and impact a wide range of novel drug modalities. This role will include a particular focus on supporting and driving circular RNA initiatives within Pfizer.

How You Will Achieve It
  • Responsible for developing advanced sample preparation and instrumental techniques across multiple biological matrices to support activities in all therapeutic areas
  • Drive experimentation and adoption of novel, optimized workflows to solve complex problems and expand our group's analytical processes and capabilities
  • As a subject matter expert on the bioanalysis of circular RNA, collaborate meaningfully both internally and externally to pursue and support key initiatives in this exciting research field
  • Communicate your scientific findings effectively to various audiences in the form of well-organized presentations and publications
  • Participate in all phases of mass spectrometry laboratory operations including instrument maintenance, the development of sample preparation and separation methods, data analysis, etc
  • Take keen interest, responsibility, and ownership for portions of our workflows that stoke your scientific curiosity


  • BS in a scientific discipline with 5+ years of bioanalytical experience OR MS in a scientific discipline with 4+ years of bioanalytical experience
  • 2-5 years of direct, hands-on experience in the operation and maintenance of LCMS (QQQ and/or HRMS) instrumentation and associated data analysis software such as Skyline
  • Expertise in biological sample preparation techniques (immunoaffinity, tryptic digestion, tissue processing, conjugation, etc) of various biofluids for proteomic analysis
  • Experience with general quantitative analysis techniques for mass spectrometry
  • Experience generating scientific collateral using Microsoft Office applications and presenting findings to audiences effectively
  • Ability to multitask as both an independent contributor and an influential team member

  • Experience in the bioanalysis of RNA therapeutics by LCMS
  • Experience in multidimensional nanoflow chromatography
  • Working understanding of protein biochemistry and quantitative protein analytical techniques
  • Prior industry experience

  • Ability to meet the standard requirements for a lab-based role and perform all typical lab related activities (lifting ≤20 pounds, frequent pipetting, long stretches on feet, etc)


  • Occasional travel to Cambridge (Kendal Square) may be required, depending on project needs
  • Flexibility to work remotely when performing non lab based functions

Other Job Details
  • Work Location Assignment: On Premise colleagues work in a Pfizer site because it's needed to get their job done. They may have flexibility to work remotely from time to time, but they are primarily on-site.


Relocation assistance may be available based on business needs and/or eligibility.


Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development
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