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Investigator, Clinical Genomics

Collegeville, Pennsylvania
Closing date
Oct 3, 2022

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Are you looking for an exciting opportunity to make an impact in the field of clinical genomics? If so, then this role is for you!

We have an exciting opportunity for a highly motivated, agile, and experienced scientist with lab level expertise in genomic technologies to join the Cellular Biomarkers Genomics group within the Bioanalysis, Immunogenicity and Biomarkers (BIB) department based in Collegeville, PA. Our group is responsible for developing genomics biomarker assays for use in clinical studies.

This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following:
  • Serve as a technical expert in applied genomic technologies and generate data to support the understanding of disease heterogeneity, drug's mechanism of action, and patient response to treatment at the molecular level through application of advanced genomic technologies, including Next Generation Sequencing (NGS), single cell analysis, Nanostring, qPCR, ddPCR etc.
  • Conduct and oversee all aspects of the method development, troubleshooting, validation, and sample analysis for clinical studies requiring genomic technologies endpoints including reagent selection/optimization, sample preparation, sample acquisition and data processing.
  • Ensure all work is conducted in compliance with GCLP regulations and follows the appropriate SOPs.

Why you?

Basic Qualifications :

We are looking for professionals with these required skills to achieve our goals:
  • B.S. degree with minimum 10 years post-graduation experience in genomics, NGS, molecular or cellular biology, biomedical science, or related disciplines
  • Knowledge of current genomic analytical platforms (e.g., RNA-Seq, metagenomics, NanoString, qPCR, ddPCR etc.)
  • Experience in designing, troubleshooting, and implementing single cell RNA-Seq applications or similar high content techniques (e.g., BD Rhapsody, 10x Genomics)
  • Experience with and scientific understanding of flow cytometry and histotechology to lead cross-platform genomics projects (e.g., CITE-Seq, TCR/BCR Seq, NanoString assays, Spatial Transcriptomics etc.)
  • Experience and understanding in the use of genomics analysis software (Genome Browser, Partek Genomics suite, CLC-Bio etc.
  • Experience working with tight or shifting deadlines, both independently and in a team
  • Experience with and working knowledge of the drug development process

Preferred Qualifications:

If you have the following characteristics, it would be a plus:
  • M.S. in Molecular Biology, Biochemistry or related field, with 8 years post-graduation experience
  • PhD in Molecular Biology, Biochemistry or related field - with minimum 2 years post-PhD experience
  • Excellent collaborator with great interpersonal skills who can build relationships to work with colleagues from all phases of clinical drug development and influence biomarker testing strategies
  • Ability to maintain a disciplined approach, ensuring a relentless focus on quality, compliance, scientific rigor, and operational excellence
  • Ability to provide guidance on the use of NGS, digital quantification of nucleic acids and single cell analysis to support clinical sample testing
  • Hands on experience with the NovaSeq, MiSeq, 10X chromium, BD Rhapsody, ddPCR, NanoString platform etc.
  • Ability to generate high quality data to support clinical studies by various NGS platforms
  • Experience conducting and overseeing all aspects of method development, troubleshooting, validation and sample analysis for clinical studies
  • Experience supporting single cell immuno-genomics works such as CITE-Seq and AbSeq (for example, cell preparation and library preparation)
  • Experience handling human biological samples and performing experimental work in accordance with safety requirements, data integrity and GCLP guidelines.
  • Experience Collaborating with Biomarker Leads and provide biomarker assay support to deliver on biomarker strategy as defined by project needs.
  • Ability to develop genomic assays using applied genomic technologies to support clinical studies, delivery of robust, high quality data packages
  • Work with data management, programming, and bioinformatics scientists to expedite the transfer of biomarker data to clinical teams
  • Deliver, interpret, and communicate complex, high quality scientific data to project/program teams within agreed timelines
  • Handle multiple projects concurrently
  • Contribute to biomarker strategy and capital equipment discussions
  • Act as subject matter expert for the transfer of assays to CROs
  • Help lead efforts to investigate novel genomics and data analysis platforms and imbed within the organization
  • Attention to detail, good communication and documentation skills
  • Willingness to develop and train others as required
  • Highly motivated team player with a proactive attitude and ability to interact effectively within a multi-disciplinary team
  • Ability to problem solve and troubleshoot
  • Ability to demonstrate judgment and decision making, especially for prioritizing multiple requests

Why GSK?

Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
  • Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigor and risk.
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Continuously looking for opportunities to learn, build skills and share learning.
  • Sustaining energy and well-being.
  • Building strong relationships and collaboration, honest and open conversations.
  • Budgeting and cost-consciousness.


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