The Director, Digital Medicine & Translational Imaging Statistics is responsible for ensuring sound statistical thinking and methods are utilized in the discovery and development of novel digital and imaging endpoints and for bringing the principles of objective decision-making into the development, validation, and implementation of industry-leading digital health technology and imaging programs for incorporation into clinical trials across Pfizer's portfolio. The Director is an integral member of a matrixed team, which develops and employs computational and statistical approaches to discover and validate digital and imaging endpoints and biomarkers. The Director must possess the ability to plan, direct and coordinate a variety of specialized and complex projects, must have knowledge of study design of experiments, data management and programming tools, and ability to interpret results from clinical studies. The Director should have ability to roll out new initiatives and assists in strategic planning. The Director should be a person of vision, should stay current on new developments and technological advancement in statistics. This person should be highly motivated and should possess excellent written and verbal communication skills. ROLE RESPONSIBILITIES
- Demonstrate leadership experience and ability to lead teams and mentor colleagues.
- Lead novel statistical methodology projects with internal and external partners to advance the development of digital and imaging endpoints for use in clinical trials.
- Serve as the lead statistician on clinical trials incorporating novel AI/ML-based technologies and novel study designs such as decentralized clinical trials.
- Bring innovative statistical thinking and methods to help drive data-driven drug discovery and development employing modern methods such as machine learning/AI, longitudinal and time series methods, multivariate and functional data analysis approaches, and Bayesian methodologies.
- Collaborate with interdisciplinary teams including clinicians, data scientists and data managers to develop, validate and deploy algorithms and analysis pipelines to derive digital endpoints for use in clinical trials.
- Ensure rigorous approaches are taken and good scientific practices are followed: excellent statistical methods utilized and documented in protocols, analysis plans and manuscripts, and assay methods are appropriately blinded, randomized and designed to meet clear study objectives.
- Provide statistical input and leadership to determine strategy and deliver results in a timely and high-quality manner. Ensure that all statistics activities are conducted in compliance with relevant regulatory requirements and Pfizer standards.
- Interact with internal and external experts to assure sound quantitative approaches are applied to the collection and analysis of a wide variety of data types, including digital health technology data, imaging, and blood-based biomarkers.
- Provide planning and communication of statistical analyses, data presentations and scientific reports, including clinical trial results, exploratory analyses and analyses that synthesize results across studies, support for publication activities, scientific presentations, and regulatory interactions.
Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact. Basic Qualifications
- PhD in Statistics, Biostatistics or in quantitative discipline such as Physics, Applied Mathematics, Bioengineering, Electrical Engineering coupled with high level of statistical expertise and 7 years or more of industrial or similar experience, or Masters in the same fields and 9 years or more of industrial or similar experience.
- Research experience with mathematical/statistical modeling using complex data.
- Technical Skills:
- Fluency in R and SAS programming
- Programming in Python
- Experience in clinical statistics supporting early / late-stage clinical development and/or real-world evidence studies.
- Expert level knowledge of machine learning algorithms, feature selection and optimization.
- Experience analyzing digital health technologies data, such as accelerometry, wearable devices and mobile app data.
- Strong background in experimental design and statistical analysis including good understanding of inference and probability, competence in contemporary linear and predictive modeling including (longitudinal) mixed models, nonlinear regression, and predictive modeling.
- Genuine interest in biology and pharmaceutical development, with the attitude of self-directed scientist; demonstrated ability to multitask.
- Outstanding communication skills; ability to explain statistical and modeling concepts to non-experts.
- Demonstrated ability to work effectively independently and as a part of a team.
OTHER JOB DETAILS
- Experience leading teams/mentoring colleagues
- Technical Skills:
- Prior use of cloud computing tools, e.g., AWS
- Knowledge of MATLAB
- Knowledge of adaptive clinical trial designs and/or cluster randomized trials is an advantage.
- Experience analyzing large scale imaging datasets.
- Knowledge of methods of signal processing
- Knowledge of functional data analysis approaches and Bayesian methods.
Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.Sunshine Act
- Eligible for Relocation Package
- Eligible for Employee Referral Bonus
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.