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Principal Scientist, Systems Immunology

Cambridge, Massachusetts
Closing date
Oct 3, 2022

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Life Sciences, Immunology, Physical Sciences, Chemistry
Position Type
Full Time
Job Type
Staff Scientist
Organization Type
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We are seeking a motivated scientist to join the Systems Immunology group within Pfizer's Inflammation and Immunology Research Unit. This individual would support the development and implementation of systems immunology (single-cell multiomics, systems pharmacology, development of translatable cellular systems, etc.) for drug development in Inflammation and Immunology's portfolio areas. This person will contribute to the execution of technical and laboratory aspects of single-cell multiomics projects, and collaboratively support drug development programs by enabling project teams to comprehensively understand drug candidates. This person must be a subject matter expert in identifying the effects of treatment perturbation using single-cell multiomics, and in the development/execution of complex sample collection from disease models. This person should also be well versed in cross-functional collaboration for drug development.

  • Contribute to the growth of single-cell multiomic methods for drug development by supporting ongoing development, execution, validation and troubleshooting of single-cell assays, including multiomic single-cell assays, for in vitro, ex vivo, and in vivo models of disease and treatment
  • Contributes to cross-functional drug development teams as a Systems Immunology representative by coordinating and supervising all 'omic experimental design and interpretation related to candidate development
  • Perform and operationalize various single-cell analysis workflows; from tissue storage, sample preparation, library construction, data generation, data processing to interpretation of results, ensuring high level of quality and reliability of generated results.
  • Performs or supervises effective optimization of tissue stabilization, dissociation, and purification protocols for use in systems pharmacology experiments
  • Serves as a subject matter resource for single-cell multiomics for drug development
  • Serves as a subject matter expert in single cell multiomic data processing and analysis workflows

  • PhD in Immunology, Pharmacology, Biology, or related discipline with 2 -- 5 years of experience in drug discovery or development
  • 1+ years of experience on a cross-functional drug development team
  • Extensive hands-on experience with single cell multiomic data generation methods
  • Extensive hands-on experience with single-cell multiomic analysis and standard bioinformatic pipelines in R or Python

  • 1+ years of experience in drug discovery or development for inflammation, immunology, or autoimmunity indications
  • Previous experience developing robust sample collection protocols for cross-functional teams
  • Previous experience with high throughput compound profiling using 'omics phenotypes
  • Previous experience identifying the function and effect of drug compounds or perturbations in complex assays
  • Previous experience profiling drug-like compounds in animal or ex vivo models of inflammation

Relocation support available

Work Location Assignment:On Premise

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development
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