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Senior Principal Scientist- Process Chemistry Group Leader

Groton, Connecticut
Closing date
Oct 3, 2022
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We are seeking an experienced Process Chemist to join our Chemical Research and Development (CRD) Team in Groton, CT. CRD, as part of Worldwide R&D and Medical in Pharmaceutical Sciences, is responsible for the development of process technology for the production of active pharmaceutical ingredients (API). This role is part of the late-stage Process Chemistry group in Groton (Process Chemistry Development and Optimization-PCDO) and pertains to serving as a leader within PCDO, as well as the completion of chemistry development activities to support clinical milestones. The position is also responsible leading teams and for successful technology transfer to our manufacturing partners Pfizer Global Supply (PGS).

The role requires both directing lab work as well as technical oversight and supervision of 2-3 process chemists. Training members of the new lab around Science of Scale is an essential responsibility, in particular around developing scalable processes which are safe, efficient and robust, use of the state-of-the-art equipment, and the use of computational and predictive tools. The role also requires the ability to serve as a subject-matter expert in process chemistry and train future leaders for CRD. Excellent communication skills are required to ensure connectivity with both the broader CRD group, as well as an ability to represent process chemistry on multi-disciplinary teams.

The successful candidate will lead project teams and develop and optimize scalable processes for the production of active pharmaceutical ingredients (API) in late-phase development programs. The application of innovative chemistries, new technologies and statistical experimental design approaches are highly desired. The ability to lead and collaborate with multi-disciplinary teams involving chemists, analysts, engineers, and technologists, and to represent CRD on cross-functional teams is essential. Partnership with manufacturing specialists for API synthesis in the Kilo Lab (Groton, CT), Process Development Facility (Sandwich, UK), and PGS (Ringaskiddy, IR) is critical, as well as preparing documentation and knowledge to support technology transfer.


  • Individual lab work may be required to ensure project readiness with a focus on documentation and achieving program milestones. The role requires developing others and the use of the state-of-the art equipment, analytical technology, computational and predictive tools to successfully deliver workflow milestones.
  • Supervision, including oversight and training, of 2-3 colleagues initially and potentially additional scientific staff in the future.
  • Responsible for mentoring colleagues to assure their career development an provide support to enable them to reach their full potential. The candidate will also be responsible to ensure timely performance feedback for direct reports
  • Strong oral communication skills including face to face and remote interactions with supervisor and other CRD colleagues in Groton/Sandwich/Ringaskiddy, as well as developing and leading strategies in collaboration with Analytical Chemistry, Quality, and Chemistry Manufacturing and Control (CMC).
  • Excellent written communication skills, including the ability to maintain an accurate scientific notebook, draft concise written reports, publications, and the authoring of regulatory documents.
  • An ability to work with legal representatives on IP/FTO strategies for portfolio assets.
  • Leading process chemistry on API project teams in the post-POC arena with the ability to manage team resources and direct work in multi-disciplinary teams involving analysts, process safety scientists, engineers, and technologists as an essential skill.
  • Partnering with remote manufacturing specialists for API synthesis in the Kilo Lab/PDF/PGS, as well as providing support for technology transfer to CMOs, including the preparation of technical transfer documents through validation and launch readiness.
  • Compliance on safety and regulatory requirements.
  • Travel is occasionally required in support of manufacture (Groton, Sandwich, Ringaskiddy) and to engage with the broader CRD team, and to participate in scientific conferences.

Leading and participating in key initiatives for CRD and contributing to continuous improvement work in the department for the advancement of the Process Chemistry discipline through technology, workflow or business impact.


  • Bachelor's Degree in chemistry and 15+ years' experience in Chemical Research and Development or MS degree in Organic Chemistry with 12+ years' experience in Chemical Research and Development or PhD in Organic Chemistry and 8+ years' experience in Chemical Research and Development.


  • PhD. in Organic Chemistry, with 8-10 years of pharmaceutical R&D experience in Process Chemistry.

  • State of the art knowledge of modern synthetic methodology, including aspects of asymmetric synthesis, green chemistry, catalysis and physical organic chemistry as it relates to reaction mechanism is expected. The ability to employ analytical tools and automated laboratory technologies to enhance process development efficiency is desirable. Excellent written and oral communication skills, the ability to effectively influence the work of others, and a general knowledge of drug development and the pharmaceutical industry are key.

  • Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.


Laboratory work requiring standing and working at a computer.


Travel may be required on occasion to Sandwich, UK or Ringaskiddy, IR in support of internal technology transfer to API manufacturing facilities or internal face-to-face meetings, or to participate in scientific conferences.

Additional Information:
  • Relocation support available
  • Eligible for Employee Referral
  • Work Location Assignment:On Premise
  • Last Date to Apply: October 17, 2022


Relocation assistance may be available based on business needs and/or eligibility.


Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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