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Clinical Biomarker Lead, Oncology Synthetic Lethality

Employer
GSK
Location
Collegeville, Pennsylvania; Zug, Switzerland; Waltham, Massachusetts
Salary
Competitive
Closing date
Oct 1, 2022

View more

Discipline
Life Sciences, Oncology
Organization Type
All Industry, Pharma
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Are you interested in developing, integrating, and implementing innovative biomarker strategies for Oncology clinical development programs, including validation and integration of biomarker assays into clinical trials? If so, the Clinical Biomarker Lead role within Experimental Medicine Unit (EMU) could be an ideal opportunity to explore.

This role will provide YOU the opportunity to lead key activities to progress YOUR career.These responsibilities include some of the following :
  • Lead and/or contribute to clinical asset biomarker strategy within early and late stage clinical development programs to generate data that informs on target engagement, pharmacodynamics, mechanism of action and patient selection.
  • Represent EMU Biomarker team at Clinical Matrix Teams (CMT) and clinical trial study teams (CST). As part of the CMT and CST, establishing clear decision-making criteria to enable biomarker-informed clinical decisions.
  • Provide input to clinical teams on biomarker-related elements of clinical protocols, lab manuals and consent forms.
  • Develop and implement novel biomarker assays.
  • Provide scientific expertise and technical guidance to enable timely biomarker sample collection.
  • Execute sample testing plan and deliver high quality biomarker data packages to inform clinical development and regulatory strategy.
  • Point contact for resolving study biomarker issues.
  • Collaborate with clinical operations and sample management to ensure biomarker testing and data generation
  • Align with the companion diagnostics team to deliver novel precision medicine approaches to select patients for treatment.
  • Serve as a point of contact for external vendors and collaborators in support of data generation.
  • Provide frequent project status updates related to biomarker deliverables.


Why You?

Basic Qualifications:
  • Ph.D. or equivalent with minimum of 2 years or MA/MS with minimum 5 years of relevant experience in pharmaceutical industry setting in the application of biomarkers in clinical trials preferably in Oncology
  • One or more years experience in conducting biomarker analyses on various clinical sample types and working as part of a clinical study team
  • One or more years experience working in matrixed, multidisciplinary teams
  • One more years experience working in a matrixed team environment


Preferred Qualifications:

If you have the following characteristics, it would be a plus:
  • Deep understanding and experience working in the Oncology or Immuno-Oncology Biomarker field
  • Experience in high-impact contributions to biomarker discovery and/or assay development
  • Experience in Correlative Science or Data Science
  • Experience in managing research collaborations, contract laboratories and budgets
  • Demonstrated scientific capability as evidenced by publications, research reports, and external presentations
  • Effective verbal and written communication skills relating to colleagues and associates both inside and outside the corporation
  • Flexibility to work on multiple projects as the portfolio evolves over time
  • Up to date knowledge and deep understanding of major molecular and genomic assay technologies and platforms
  • Knowledge and track-record of working to GCP principles
  • Having a strong sense of urgency and excellent skills in prioritization, planning as well as timely execution in a very fast-paced environment
  • Strong interpersonal skills and ability to thrive in a matrix environment


Why GSK?

At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader inConsumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggestchanges we've made to our business in over 20 years. We're on track to separate and create two new companies in 2022: New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and geneticsscience; and a new world-leading consumer healthcare company of loved and trusted brands.​



With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of diseasetogether - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; andas a new GSK where outstanding people thrive.​



Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culturethat is ambitious for patients - so we deliver what matters better and faster; accountable for impact - with clear ownership ofgoals and support to succeed; and where we do the right thing . So, if you're ready to improve the lives of billions, join us at thisexciting moment in our journey. Join our challenge to get Ahead Together.


*LI-GSK


GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years.

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We're committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve.

GSK has made the decision to require all US employees to be fully vaccinated against COVID-19, where allowed by state or local law and where vaccine supply is readily available. The only exceptions to this requirement are employees who are approved for an accommodation for religious, medical or disability-related reasons.

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