Scientific Investigator - Safety Pharmacology - In Vivo Cardiovascular Expert

Employer
GSK
Location
Collegeville, Pennsylvania
Salary
Competitive
Closing date
Oct 2, 2022
Are you looking for a role where you will provide specialized scientific and translational expertise for drug discovery and development? If so, this, Investigator role could be an ideal opportunity to explore.

The Safety Pharmacology group in Non-Clinical Safety, In Vitro/In Vivo Translation is a resource focused on the proactive management of safety pharmacology issues and their translation to man. Safety Pharmacology supports all therapeutic areas from idea to loss of exclusivity including experimental approaches to aid target and compound selection, regulatory pre-FIH safety studies and post-FIH investigative studies to address clinical findings and manage risk. The broad remit of the department requires strong discipline expertise and a clear and strong interface with the portfolio.

This position is an exciting opportunity to make a difference in the lives of patients by applying human physiology and pharmacology expertise coupled with translational knowledge and industry experience to drive drug discovery and development.

As an Investigator in Safety Pharmacology, you will be responsible for conducting and summarizing in vivo cardiovascular safety studies on new drug substances, including regulatory input. You will also help manage non-clinical safety strategies and programs across the function.

This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:

  • This individual will be based in Upper Providence, PA, USA and will work within the Safety Pharmacology discipline.
  • Overall responsibility for the technical conduct of the in vivo cardiovascular Safety Pharmacology studies, as well as for, the interpretation, analysis, documentation, and reporting of results (including Safety Pharmacology endpoints in General Toxicology studies) and represents the single point of study control (study director).
  • The role is for a subject matter expert in human cardiovascular physiology, pharmacology, or toxicology with an emphasis on Safety Pharmacology.
  • The role will be part lab based and will require the design, conduct and interpretation of in-vivo studies to support the safety pharmacology assessment of projects across the portfolio.
  • Provide strategic advice, implementing de-risking strategies and influencing partners.
  • Use the scientific literature and available in-house data to design and interpret studies.
  • Engage in the discussion and interpretation of data beyond their own discipline. This will include working with subject matter experts in other disciplines including those in Safety Pharmacology i.e. CNS, Respiratory, ion channels and in vitro pharmacology as well as other specialties.
  • Prepare study protocols, reports, amendments, and deviations in accordance with all applicable laws and regulations including, but not limited to, Good Laboratory Practices (GLPs; 21 CFR Part 58), Institutional Animal Care and Use Committee (IACUC) guidelines, Regulatory Agency guidelines and regulations, and departmental Standard Operating Procedures.
  • Additional duties may include project team membership, contributions to development of capabilities, and interacting with strategically aligned public private partnerships.


Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:
  • PhD or MD/PhD with minimum of 1 year Post-Doctoral research experience in cardiovascular physiology/pharmacology or other relevant field
  • Experience designing, conducting, and interpreting in vivo cardiovascular studies in both small and large animals.
  • Experience of working as part of discovery project teams, and experience incorporating a drug safety strategy into a project strategy.
  • Experience with integration of large data sets from multiple sources, to develop and communicate an understanding of the issue and associated risk.
  • Experience leading scientific projects.
  • Experience mentoring/coaching junior colleagues.
  • Experience with laboratory instrumentation and data collection tools. Experience with the application of statistical approaches to the analysis of in vivo data.


Preferred Qualifications:
  • Minimum of 3 years pharmaceutical or biotechnology industry research experience working in relevant field
  • Scientific expertise knowledge and work experience in cardiovascular safety
  • Experience representing Pharma or interacting with external partners (e.g. CROs, academic groups).
  • Ability to solve problems
  • Knowledge of regulatory requirements and drug development process
  • Leadership skills
  • Ability to work in a matrix environment
  • Effective communicator
  • Project management experience


Why GSK?

We're combining the power of genetic and genomic insights into what causes disease, with the speed and scale of artificial intelligence and machine learning (AI/ML) to make better predictions about who a treatment might work for, and why. We believe this powerful combination of data and technology holds the key to fundamentally transforming medical discovery for the better, improving R&D success rates and shaping how even the most challenging diseases, like neurological conditions and cancer, can be both prevented and treated.

In 2021 we delivered four major product approvals: Cabenuva for HIV, Jemperli for endometrial cancer, Xevudy for COVID-19 and Apretude , our new long-acting medicine for HIV prevention.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

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