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Associate Scientist, In vitro ADME/Biology Specialist

Employer
Pfizer
Location
Groton, Connecticut
Salary
Competitive
Closing date
Sep 30, 2022

View more

Discipline
Life Sciences, Biology, Physical Sciences, Chemistry
Position Type
Full Time
Job Type
Staff Scientist
Organization Type
Pharma
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Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

ROLE SUMMARY

  • This scientist will provide high quality in vitro plate-based ADME, safety and biopharmaceutical data to project teams to enable rapid decision making in support of the Worldwide Research and Development (WRD) portfolio. A key responsibility for this group includes supporting Hit Discovery and Optimization's (HDO) screening modules.
  • This scientist will play a key role in optimizing the workflows, logistics and flexible resources involved in producing data related to the HDO screening module.
  • This scientist will provide support for the HDO screening modules outputs to WRD project teams.
  • This scientist will play a key role in developing, optimizing and validating ADME, safety and biopharmaceutical assays and workflows using cutting edge in vitro models and technology solutions.This scientist will partner with Medicines Design project team members, Discovery Sciences counterparts and CROs and contractors to deliver on the portfolio.

ROLE RESPONSIBILITIES

The successful candidate will join a team of scientists within the Hit Discovery and Optimization (HDO) group which is focused on the design, optimization, implementation and execution of in vitro plate-based assays supporting early research unit portfolios. This group drives the evaluation and utilization of novel plate-based screening sciences, technologies and workflows to improve or add capabilities within ADME, safety and biopharmaceutical property evaluation. Finally, the group interacts with project teams and counterparts as points of accountability to support and drive impactful use and design of HDO's screening modules.

The primary responsibilities of this role will include the support of HDO's screening modules, with a focus on continuous improvement, and to interface with client groups and counterparts to serve as the primary point of contact for the screening module assays. The role may be required to interact with external data providers and / or contingent workers, including oversight to ensure high quality data is being produced. Familiarity and/or comfort with high-throughput screening techniques and data acquisition and analysis software is of advantage. Previous industrial experience in applying ADME, safety or biopharmaceutical assays to solve scientific questions or supporting a project and delivering data are a plus. The successful candidate should possess strong collaborative and written/verbal communication skills and an enthusiastic, optimistic attitude.

Successful candidates will be expected to:
  • Develop, optimize and validate assays as well as execute plate-based in vitro assays and data analysis.
  • Have an understanding and ability to optimize and troubleshoot logistics and workflows utilized to execute HDO's screening modules.
  • Have experience with multiple ADME, safety and / or biopharmaceutical in vitro assay formats.
  • Display consistent proficiency in automated data acquisition, analysis and quality control; provide timely, high quality data to project teams.
  • Use robotics and automation in the performance of screening.
  • Maintain up to date electronic laboratory notebooks and records in accordance with Pfizer policy.
  • Comply with all safety training and good laboratory practices.


Additional role attributes:-
  • Contributes to achievement of goals at the work group/ project team.
  • Applies technical skills and functional knowledge to projects/ assignments within own work group/ project team.
  • May use or develop novel processes or hypotheses.
  • Manages own time to meet agreed targets; develops plans for short-term work activities on own projects (timelines, work plans, deliverables).
  • Works under limited supervision with periodic review of achievement of results and methods used.

QUALIFICATIONS
  • Minimum qualification - BS in a relevant science (e.g., biology, chemistry, or Pharmacy) with relevant interest in drug discovery in ADME, safety, biology, cell biology, or chemistry.
  • Preferred experience in a laboratory working as part of a multi-disciplinary team focused on delivering in vitro ADME, safety and /or biopharmaceutical data.
  • Preferred experience developing new plate-based ADME, safety or biopharmaceutical assay.
  • Preferred experience with standard in vitro ADME, safety, and/or biopharmaceutical assays (e.g. microsomal stability, transporter assays, physical properties assays), including assay execution and troubleshooting.
  • Strong track record of delivering high quality data.
  • Successful experience partnering with stakeholder groups and maintaining a customer focus.
  • Excellent computer, verbal and written communication skills

Work Location Assignment: On Premise

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Relocation assistance may be available based on business needs and/or eligibility.

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Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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