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Senior Scientist, Functional Genomics

Employer
Pfizer
Location
Cambridge, Massachusetts
Salary
Competitive
Closing date
Sep 30, 2022

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Discipline
Life Sciences, Genomics, Physical Sciences, Chemistry
Position Type
Full Time
Job Type
Senior Scientist
Organization Type
Pharma
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Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

Pfizer is using human genetics to inform the discovery and validation of new drug targets and the mechanistic understanding of disease pathology. A necessary component of genetic studies applied to drug discovery is testing of the functional consequences of disease-associated genes and variants. Pfizer's Functional Genomics group, with labs in both Cambridge and New York City , is launching the Functional Genomics Technology Center at our Cambridge site. Working closely with disease biologists across therapeutic areas, the Functional Genomics Tech Center applies the latest experimental gene editing tools and novel screening approaches to bring the best new targets into the portfolio and deepen our knowledge of targets under development.

We are seeking an experienced molecular biologist, with expertise in gene editing and functional genomics screening, to contribute to the success of the new Functional Genomics Tech Center in Cambridge. This is an exciting opportunity to apply cutting-edge methods and contribute to the target portfolio of one of the world's leading developers of novel therapeutics.

How You Will Achieve It

  • Apply a versatile repertoire of gene editing and molecular biological tools to rapidly test the functional consequences of genes and variants in appropriate cell-based model systems
  • Design and conduct functional genomics screens in pooled and arrayed formats
  • Support screening and technology development projects related to key emerging science areas, and develop and internalize new and innovative screening strategies
  • Analyze screens and work with genetics, computational, and other colleagues to identify and champion new targets
  • Work with external providers, when appropriate, to expand capabilities in the functional genomics space
  • Stay current with gene editing and related technologies in order to evaluate new approaches and incorporate improvements
  • Work closely with other Functional Genomics lab personnel in Cambridge and New York City.
  • Collaborate closely and maintain productive relationships with disease area biologists and other Tech Center colleagues (NGS, FACS, Imaging, and Mass Spec).
  • Serve as a technical resource for gene editing and other gene modulation technologies


Qualifications

Must-Have
  • PhD degree in molecular biology or related field with at least three years of postdoctoral experience
  • Track record of successful contribution to research projects, leading to project advancement and/or peer-reviewed publications, preferably utilizing gene editing methodologies
  • Hands-on experience with gene editing and high-throughput functional genomics screening
  • Expertise in molecular and cell biology, including experience with tissue culture
  • Previous experience in disease-focused research, particularly in immune/inflammatory diseases, metabolic diseases, or cancer
  • Experience developing and analyzing cell-based assays
  • Experience with NGS-based readouts from pooled functional genomics screens
  • Ability to work independently and balance multiple projects simultaneously
  • Excellent interpersonal and communication skills to effectively collaborate with other scientists


Nice-to-Have

  • Experience evaluating and implementing new techniques, particularly in the field of gene editing
  • Familiarity with computational approaches to target discovery is a plus


Other Job Details
  • Eligible for relocation support
  • Work Location Assignment:On Premise. On Premise colleagues work in a Pfizer site because it's needed to get their job done. They may have flexibility to work remotely from time to time, but they are primarily on-site.


#LI-PFE

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Relocation assistance may be available based on business needs and/or eligibility.

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Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development
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