Reporting to the Director, Discovery DMPK UP Site, you will be responsible for managing the implementation of a global in vitro DMPK strategy and be accountable for local US DMPK hub delivery of precandidate profiling studies. These will be used to inform project teams of the clinical translation of the in vitro ADME data and to provide information to develop predict first models to aid medicinal chemistry design. This includes proactively identifying and mitigating key development risks related to ADME properties of NCEs. This role has a significant impact on progression decisions for lead optimization projects and precandidate selection profiling activities. This leadership role also has accountability for contributing to developing the DMPK in vitro strategy with key partners. The development and supervision of a local hub team of scientists responsible for the delivery of those in vitro DMPK studies. Furthermore, the position will work with Discovery and Development partners to deliver an integrated DMPK package to allow early preclinical estimation of human pharmacokinetics. Key Responsibilities:
- Provides single point accountability for US hub discovery DMPK in vitro support for projects and research driven initiatives.
- Manage and develop a highly skilled group of bench scientists in their daily activities to encourage focused innovative research linked with critical lead optimization activities.
- Accountable with other in vitro hub leaders to ensure work packages, experimental designs, conduct and data archiving of in vitro DMPK studies are robust, consistent, documented (e.g., qualified as appropriate with current scientific standards) and meet GSK / regulatory data standards (e.g., captured accurately in the appropriate corporate data repository).
- Aligns approaches and technologies with the other in vitro hub leads.
- Will identify and adopt the use of automation techniques and process improvements to increase the efficiency of the in vitro group.
- Provide direction to resolve technical challenges and deliver results in a timely manner.
- Report and communicate scientific ideas and results to senior leaders as needed as well as authoring and/or approving regulatory reports ahead of project milestones.
- Local hub responsibility to manage equipment and facility resources in a collaborative manner.
- Define the scientific strategy of the accountable in vitro DMPK team, annual objectives and individual performance monitoring.
- Works closely with subject matter experts, Project Specialists and other functional lines to ensure that technologies and science are relevant for project team and portfolio deliverables.
- Develop partnerships with external collaborators: identifying appropriate collaborators (CROs, academics or others), and work effectively with them designing studies and interpreting results.
- Encourage and develop the use of QSAR modelling in order to drive compounds design/make/test cycle.
- Drive the scientific rigor and integrity of the data collected within their team as well as the conclusions derived and demonstrate this through internal and external publication and presentation.
- Fosters a culture of continuous improvement in line with GSK Innovation/Performance/Trust/culture strategy.
- Ensure compliance with GSK Values and Policies.
- BSc in a science subject such as Drug Metabolism, Pharmacokinetics, Pharmacology, Biology, Toxicology, Biochemistry, Physiology or similar subject.
- 5+ years of experience in a drug discovery pharmacokinetics setting
- PhD in a science subject such as Drug Metabolism, Pharmacokinetics, Pharmacology, Biology, Toxicology, Biochemistry, Physiology or similar subject.
- A demonstrated track record of managerial experience and an ability to set and deliver on short and longer-term strategy
- Strong leadership skills demonstrating vision and strategy and effective leadership of change.
- Ability to work routinely across boundaries and establish cross functional matrix groups.
- Ability to coach/mentor, develop and performance manage staff.
We're combining the power of genetic and genomic insights into what causes disease, with the speed and scale of artificial intelligence and machine learning (AI/ML) to make better predictions about who a treatment might work for, and why. We believe this powerful combination of data and technology holds the key to fundamentally transforming medical discovery for the better, improving R&D success rates and shaping how even the most challenging diseases, like neurological conditions and cancer, can be both prevented and treated.
In 2021 we delivered four major product approvals: Cabenuva for HIV, Jemperli for endometrial cancer, Xevudy for COVID-19 and Apretude , our new long-acting medicine for HIV prevention. Find out more: Our approach to R&D
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