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Postdoctoral Fellow, Computational Safety Sciences

Employer
Pfizer
Location
Remote, Remote, United States;
Salary
Competitive
Closing date
Sep 30, 2022

View more

Discipline
Life Sciences, Computational Biology
Position Type
Full Time
Job Type
Postdoc Fellowship
Organization Type
Pharma
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Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

We have an exciting postdoctoral fellow opportunity to join Pfizer's Drug Safety Research and Development group in the Groton, CT Pfizer site. This postdoctoral fellow will study the hazard associated with gene perturbation, focusing on the context of viral integration following gene therapy. They can use systematics or statistical approaches (ML/AI) to develop a quantitative model of integration detection and hazard associated with viral integration profiles.

We are seeking a well-trained scientist with skills in toxicology, bioinformatics or computational biology who is also interested and passionate about getting training across disciplines. Your scientific research will give you the opportunity to immerse yourself in a dynamic pharmaceutical industry environment, to work with, learn from, and to influence fellow scientists. You will be expected to deliver the results of your novel research internally via various working groups, via external conferences and through publications in quality scientific journals.

How You Will Achieve It
  • Develop and validate pipelines for identifying integration from short and long-read sequencing platforms (preferable languages are R, python, and shell, but others are considered)
  • Identify, collect, and analyze externally available integration datasets in a systematic fashion
  • Create a quantitative understanding of hazard associated with gene perturbation in the context of viral integration
  • Communicate your research regularly across stakeholders in various groups both internally and externally
  • Assist or lead analyses of other data generated to answer research questions around viral integration.


QUALIFICATIONS

Must-Have

  • Ph.D. in Biological Sciences, Toxicology, Computational Biology, or related field
  • Strong communication skills (verbal and written). Ability and desire to share their research and findings to a broad spectrum of scientists
  • A solid foundation in a coding language (R or python) with excitement to dive into spending most or all their time on computational analyses


Nice-to-Have

  • Intimate understanding of the concepts of gene therapy and viral integration
  • Experience with both bench and bioinformatic analyses that relate to viral integration
  • Familiarity with computational clusters and any submission environment (Slurm, lustre or others)
  • A great candidate may not meet all the criteria above. They should come with a strong background in science, some computational skills and a strong desire to dive deep into this important and complex question in a team of driven scientists.


PHYSICAL/MENTAL REQUIREMENTS

Ability to perform mathematical calculations and ability to perform complex data analysis.

OTHER JOB DETAILS

Additional Job Location: US Remote

Eligible for Relocation Assistance

Eligible for Employee Referral Bonus

Must Have Work Authorization in the US

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Relocation assistance may be available based on business needs and/or eligibility.

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Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development
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